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- W2026466233 abstract "Aim: The c-myc proto-oncogene is over-expressed in synoviocytes from patients with rheumatoid arthritis (RA). For improving the inhibition of c-myc antisense oligodeoxynucleotides (AS ODN) on RA synoviocytes proliferation, we used two antisense sequences: one (antimyc-AUG AS ODN) targeting the initiation codon (AUG) and the next four codons on c-myc mRNA; another (antimyc-CRD AS ODN) targeting the coding region determinant (CRD) on c-myc mRNA to investigate if there was a difference on inhibiting synoviocytes proliferation.Methods: Cultured human synoviocytes from patients with RA. The sequences were modified by phosphorothioates. Lipofectin was used as carrier. MTT assay was used to examine the inhibition of cell proliferation.Results: Antimyc-AUG AS ODN and antimyc-CRD AS ODN both can inhibit synoviocytes proliferation dose-dependently. The maximum decrement of cell number was 40% at 2.5 µM and 48 h, 41.4% at 5 µM and 48 h, respectively. The action time of antimyc-AUG AS ODN inhibiting synoviocytes proliferation was earlier than that of antimyc-CRD AS ODN. ODN at high levels had non-sequence-specific cytotoxicity.Conclusions: Both c-myc AS ODN are useful in inhibiting synoviocytes proliferation." @default.
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- W2026466233 date "2004-09-01" @default.
- W2026466233 modified "2023-10-14" @default.
- W2026466233 title "Inhibition of synoviocytes proliferation by two types of c-myc antisense oligodeoxynucleotides" @default.
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- W2026466233 doi "https://doi.org/10.1111/j.1479-8077.2004.00072.x" @default.
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