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• W2026475602 abstract "We have already demonstrated (1) that in vitro gliadin challenge of treated coeliac intestine, is effective in inducing intraepithelial migration of CD3+ cells. This migration is observed after 24 hours of organ culture and the CD3+ cells are apparently un-activated (CD25-). Therefore this T cell migration seems not to be caused by direct antigenic activation of the migrating CD3+ cells. In this study we have tested if IL15 may control this migration. This cytokine was chosen because of its reported effects on T cell migration in rheumatoid arthritis, where induces recruitment of T cells into the synovial membrane (2). Furthermore it is known that IL-15 is a growth factor for γ/δ T cells(3), a T cell sub-population which play a yet undefined role in coeliac disease (CD). Methods. 10 intestinal treated CD biopsies were cultured in vitro for 24 hours (1) in the presence of medium alone, or added with IL15 (10 ng/ml). Tissue specimens were therefore analysed by immunocytochemistry, by anti-CD3 (Dako, 1:200) and γ/δ (Dako 1:30) MoAbs by peroxidase staining technique (1). IL15+ cells in lamina propria were detected by anti-IL15 MoAb (M110, 1:100) in untreated CD mucosa (N=7), in 6 treated CD and in 6 controls Morphometric analysis was done as previously reported (1). Student's test as well as non parametric tests were used for analysis of the data. Results. The number of intraepithelial (IE) CD3+ cells was higher after IL15 treatment than after medium alone (mean 65.6/mm epithelim, ± 24, vs 27.2 ± 10.2 with medium alone, p<0.01). The number of CD8+ cells (44.5±15.9, vs 21.1±7.41, p<0.01) as well as of γ/δ+ cells (26.5±9.3, vs 8±2.7, p<0.01) was increased, whereas that of CD4+ cells was not(p = NS). The number of lamina propria mononuclear cells which express IL15 was higher in untreated CD intestine, than in treated CD or controls (17.4±10.8 per mm2 of lamina propria, vs 6.8±5.5 in controls, p<0.05 and vs 4.5±3 in treated CD, p<0.05). Conclusions. In treated CD intestine IL15 is effective in inducing migration of CD8+ and γ/δ+ cells to the surface epithelium. Moreover IL15 expression is higher in untreated CD than in treated and in controls. These results indicate that IL15 is the likely candidate cytokine modulating IE infiltration of T cells and therefore may play a role in the pathogenesis of CD." @default.
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• W2026475602 modified "2023-10-18" @default.
• W2026475602 title "IL15 IS ABLE TO INDUCE MIGRATION OF CD3+CD8+ AND γ/δ+ T CELLS TO THE SURFACE EPITHELIUM IN COELIAC SMALL INTESTINAL MUCOSA" @default.
• W2026475602 doi "https://doi.org/10.1097/00005176-199704000-00021" @default.
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