FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026475737> ?p ?o ?g. }

• W2026475737 endingPage "184" @default.
• W2026475737 startingPage "177" @default.
• W2026475737 abstract "Human conditions of elevated interleukin-6 (IL-6) and transgenic mice overexpressing IL-6 have increased proteolytic degradation of insulin-like growth factor binding protein (IGFBP)-3. In addition, IL-6 alters the hepatic expression of insulin-like growth factor-I (IGF-I) and the IGFBPs in vitro. The aim of the present study was to investigate whether moderately elevated IL-6 levels have short-term effects on circulating IGF-I, IGFBP-1 and IGFBP-3 proteolysis in vivo. Healthy men received a 3-h IL-6 (n = 6) or saline (n = 6) infusion and blood samples were collected prior to and up to 8 h after the start of infusion. Free IGF-I, total IGF-I, IGFBP-1, insulin and cortisol were measured using immunoassays. Serum IGFBP-3 proteolysis was analyzed by Western immunoblot and by in vitro degradation of ¹²⁵I-IGFBP-3. We found that IL-6 concentrations reaching approximately 100 pg/ml significantly increased IGFBP-1 after the end of infusion in the absence of changes in insulin. In addition, plasma levels of cortisol were increased in response to IL-6 during and after infusion compared to saline. There was no effect of IL-6 on IGFBP-3 proteolysis, total IGF-I or free dissociable IGF-I. These data suggest that moderately elevated levels of IL-6 such as in the post-operative state or after exercise may contribute to increased levels of IGFBP-1. Although this study does not exclude that high levels and/or prolonged exposure to IL-6 may induce IGFBP-3 proteolysis in sepsis or chronic inflammatory disease, it suggests that IL-6 released from exercising skeletal muscle is not directly involved in proteolysis of circulating IGFBP-3." @default.
• W2026475737 created "2016-06-24" @default.
• W2026475737 creator A5031553937 @default.
• W2026475737 creator A5042335012 @default.
• W2026475737 creator A5042402725 @default.
• W2026475737 creator A5044480785 @default.
• W2026475737 creator A5091282427 @default.
• W2026475737 date "2006-01-01" @default.
• W2026475737 modified "2023-10-16" @default.
• W2026475737 title "Acute Interleukin-6 Infusion Increases IGFBP-1 but Has No Short-Term Effect on IGFBP-3 Proteolysis in Healthy Men" @default.
• W2026475737 cites W1578799040 @default.
• W2026475737 cites W1770900210 @default.
• W2026475737 cites W1966767506 @default.
• W2026475737 cites W1974251601 @default.
• W2026475737 cites W1976822499 @default.
• W2026475737 cites W1994860638 @default.
• W2026475737 cites W1999920704 @default.
• W2026475737 cites W2001492668 @default.
• W2026475737 cites W2006393438 @default.
• W2026475737 cites W2024144587 @default.
• W2026475737 cites W2027708075 @default.
• W2026475737 cites W2041555311 @default.
• W2026475737 cites W2051224397 @default.
• W2026475737 cites W2056387841 @default.
• W2026475737 cites W2063641138 @default.
• W2026475737 cites W2068310051 @default.
• W2026475737 cites W2069107191 @default.
• W2026475737 cites W2075326692 @default.
• W2026475737 cites W2081096579 @default.
• W2026475737 cites W2081905330 @default.
• W2026475737 cites W2095025167 @default.
• W2026475737 cites W2098882931 @default.
• W2026475737 cites W2104742870 @default.
• W2026475737 cites W2111074957 @default.
• W2026475737 cites W2114280375 @default.
• W2026475737 cites W2130078845 @default.
• W2026475737 cites W2134644322 @default.
• W2026475737 cites W2138022955 @default.
• W2026475737 cites W2145229644 @default.
• W2026475737 cites W2153868160 @default.
• W2026475737 cites W2155638038 @default.
• W2026475737 cites W2155824086 @default.
• W2026475737 cites W2169741460 @default.
• W2026475737 cites W2171663131 @default.
• W2026475737 cites W2175474731 @default.
• W2026475737 cites W2262250683 @default.
• W2026475737 cites W4232339153 @default.
• W2026475737 cites W4235046473 @default.
• W2026475737 cites W4247114438 @default.
• W2026475737 cites W4247740712 @default.
• W2026475737 cites W4248085881 @default.
• W2026475737 cites W4252419580 @default.
• W2026475737 cites W4255992648 @default.
• W2026475737 doi "https://doi.org/10.1159/000092119" @default.
• W2026475737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16549931" @default.
• W2026475737 hasPublicationYear "2006" @default.
• W2026475737 type Work @default.
• W2026475737 sameAs 2026475737 @default.
• W2026475737 citedByCount "13" @default.
• W2026475737 countsByYear W20264757372013 @default.
• W2026475737 countsByYear W20264757372015 @default.
• W2026475737 countsByYear W20264757372016 @default.
• W2026475737 countsByYear W20264757372019 @default.
• W2026475737 crossrefType "journal-article" @default.
• W2026475737 hasAuthorship W2026475737A5031553937 @default.
• W2026475737 hasAuthorship W2026475737A5042335012 @default.
• W2026475737 hasAuthorship W2026475737A5042402725 @default.
• W2026475737 hasAuthorship W2026475737A5044480785 @default.
• W2026475737 hasAuthorship W2026475737A5091282427 @default.
• W2026475737 hasConcept C126322002 @default.
• W2026475737 hasConcept C134018914 @default.
• W2026475737 hasConcept C150903083 @default.
• W2026475737 hasConcept C170493617 @default.
• W2026475737 hasConcept C181199279 @default.
• W2026475737 hasConcept C185592680 @default.
• W2026475737 hasConcept C202751555 @default.
• W2026475737 hasConcept C207001950 @default.
• W2026475737 hasConcept C2775960820 @default.
• W2026475737 hasConcept C2777397205 @default.
• W2026475737 hasConcept C2778690821 @default.
• W2026475737 hasConcept C2779306644 @default.
• W2026475737 hasConcept C2780378035 @default.
• W2026475737 hasConcept C2780689927 @default.
• W2026475737 hasConcept C2781307694 @default.
• W2026475737 hasConcept C55493867 @default.
• W2026475737 hasConcept C71924100 @default.
• W2026475737 hasConcept C74172505 @default.
• W2026475737 hasConcept C86803240 @default.
• W2026475737 hasConceptScore W2026475737C126322002 @default.
• W2026475737 hasConceptScore W2026475737C134018914 @default.
• W2026475737 hasConceptScore W2026475737C150903083 @default.
• W2026475737 hasConceptScore W2026475737C170493617 @default.
• W2026475737 hasConceptScore W2026475737C181199279 @default.
• W2026475737 hasConceptScore W2026475737C185592680 @default.
• W2026475737 hasConceptScore W2026475737C202751555 @default.
• W2026475737 hasConceptScore W2026475737C207001950 @default.
• W2026475737 hasConceptScore W2026475737C2775960820 @default.
• W2026475737 hasConceptScore W2026475737C2777397205 @default.

• next