Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026480920> ?p ?o ?g. }
- W2026480920 endingPage "1647" @default.
- W2026480920 startingPage "1639" @default.
- W2026480920 abstract "The spatial configuration of amiodarone (in both its protonated and neutral forms) and a hydroxylated analog was studied using conformational analysis in a simulated membrane-water environment. The three compounds and cholesterol were studied as isolated molecules and in interaction with lysophosphatidylcholine. The association of the molecules with lysophosphatidylcholine was further characterized by incorporation in a phosphatidylcholine matrix. Calculation of the mean interaction energy, the surface charge density and the hydrophilic and hydrophobic mean molecular areas showed that the protonated form of amiodarone, and to a lesser extent cholesterol form a stable association with lysophosphatidylcholine. This association was further stabilized when incorporated into a phospha-tidylcholine matrix so that the mean interaction energy increased to −96.1 kJ/mol (i.e. 60% higher than the mean lipid-lipid energy of interaction). Lysophosphatidylcholine was shown to possess a coneshaped structure whilst amiodarone was shown to be in the form of an inverted cone. This association of the two cones forms a stable cylindrical structure." @default.
- W2026480920 created "2016-06-24" @default.
- W2026480920 creator A5050533193 @default.
- W2026480920 creator A5079413672 @default.
- W2026480920 date "1991-06-01" @default.
- W2026480920 modified "2023-10-18" @default.
- W2026480920 title "A conformational analysis study of the interaction of amiodarone and cholesterol with lysophosphatidylcholine" @default.
- W2026480920 cites W1512648577 @default.
- W2026480920 cites W1529329924 @default.
- W2026480920 cites W1534025508 @default.
- W2026480920 cites W1596924664 @default.
- W2026480920 cites W1971836911 @default.
- W2026480920 cites W1979046104 @default.
- W2026480920 cites W1979729560 @default.
- W2026480920 cites W1994747574 @default.
- W2026480920 cites W1995440582 @default.
- W2026480920 cites W2024065050 @default.
- W2026480920 cites W2031488848 @default.
- W2026480920 cites W2043640169 @default.
- W2026480920 cites W2062091601 @default.
- W2026480920 cites W2066029950 @default.
- W2026480920 cites W2067370669 @default.
- W2026480920 cites W2078153934 @default.
- W2026480920 cites W2082747578 @default.
- W2026480920 cites W2087598227 @default.
- W2026480920 cites W2089291005 @default.
- W2026480920 cites W2093231887 @default.
- W2026480920 cites W2095112443 @default.
- W2026480920 cites W2112434149 @default.
- W2026480920 cites W2144105135 @default.
- W2026480920 cites W2158514147 @default.
- W2026480920 cites W2171074980 @default.
- W2026480920 doi "https://doi.org/10.1016/0006-2952(91)90164-z" @default.
- W2026480920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2043153" @default.
- W2026480920 hasPublicationYear "1991" @default.
- W2026480920 type Work @default.
- W2026480920 sameAs 2026480920 @default.
- W2026480920 citedByCount "10" @default.
- W2026480920 crossrefType "journal-article" @default.
- W2026480920 hasAuthorship W2026480920A5050533193 @default.
- W2026480920 hasAuthorship W2026480920A5079413672 @default.
- W2026480920 hasConcept C12554922 @default.
- W2026480920 hasConcept C126322002 @default.
- W2026480920 hasConcept C145148216 @default.
- W2026480920 hasConcept C178790620 @default.
- W2026480920 hasConcept C185592680 @default.
- W2026480920 hasConcept C22499117 @default.
- W2026480920 hasConcept C2776330855 @default.
- W2026480920 hasConcept C2778094803 @default.
- W2026480920 hasConcept C2778163477 @default.
- W2026480920 hasConcept C2778596009 @default.
- W2026480920 hasConcept C2778918659 @default.
- W2026480920 hasConcept C2779161974 @default.
- W2026480920 hasConcept C30095370 @default.
- W2026480920 hasConcept C32909587 @default.
- W2026480920 hasConcept C41625074 @default.
- W2026480920 hasConcept C55493867 @default.
- W2026480920 hasConcept C71240020 @default.
- W2026480920 hasConcept C71924100 @default.
- W2026480920 hasConcept C86803240 @default.
- W2026480920 hasConceptScore W2026480920C12554922 @default.
- W2026480920 hasConceptScore W2026480920C126322002 @default.
- W2026480920 hasConceptScore W2026480920C145148216 @default.
- W2026480920 hasConceptScore W2026480920C178790620 @default.
- W2026480920 hasConceptScore W2026480920C185592680 @default.
- W2026480920 hasConceptScore W2026480920C22499117 @default.
- W2026480920 hasConceptScore W2026480920C2776330855 @default.
- W2026480920 hasConceptScore W2026480920C2778094803 @default.
- W2026480920 hasConceptScore W2026480920C2778163477 @default.
- W2026480920 hasConceptScore W2026480920C2778596009 @default.
- W2026480920 hasConceptScore W2026480920C2778918659 @default.
- W2026480920 hasConceptScore W2026480920C2779161974 @default.
- W2026480920 hasConceptScore W2026480920C30095370 @default.
- W2026480920 hasConceptScore W2026480920C32909587 @default.
- W2026480920 hasConceptScore W2026480920C41625074 @default.
- W2026480920 hasConceptScore W2026480920C55493867 @default.
- W2026480920 hasConceptScore W2026480920C71240020 @default.
- W2026480920 hasConceptScore W2026480920C71924100 @default.
- W2026480920 hasConceptScore W2026480920C86803240 @default.
- W2026480920 hasIssue "11" @default.
- W2026480920 hasLocation W20264809201 @default.
- W2026480920 hasLocation W20264809202 @default.
- W2026480920 hasOpenAccess W2026480920 @default.
- W2026480920 hasPrimaryLocation W20264809201 @default.
- W2026480920 hasRelatedWork W152287468 @default.
- W2026480920 hasRelatedWork W1979035221 @default.
- W2026480920 hasRelatedWork W1991208694 @default.
- W2026480920 hasRelatedWork W2020188774 @default.
- W2026480920 hasRelatedWork W2020904917 @default.
- W2026480920 hasRelatedWork W2021678613 @default.
- W2026480920 hasRelatedWork W2026480920 @default.
- W2026480920 hasRelatedWork W2052003307 @default.
- W2026480920 hasRelatedWork W2330704879 @default.
- W2026480920 hasRelatedWork W2792258495 @default.
- W2026480920 hasVolume "41" @default.
- W2026480920 isParatext "false" @default.
- W2026480920 isRetracted "false" @default.
- W2026480920 magId "2026480920" @default.