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• W2026487669 abstract "Background Mitochondrial superoxide radical (O2•¯) production increases after cardiac ischemia/reperfusion (IR). Ischemic preconditioning (IPC) preserves mitochondrial function and attenuates O2•¯ production, but the mechanism is unknown. Mitochondrial membrane potential (mΔΨ) is known to affect O2•¯ production; mitochondrial depolarization decreases O2•¯ formation. We examined the relationship between O2•¯ production and mΔΨ during IR and IPC. Materials/methods Rat hearts were subjected to Control or IPC. Mitochondria were isolated at end equilibration (End EQ), end ischemia (End I), and end reperfusion (End RP). mΔΨ was measured using a tetraphenylphosphonium electrode. Mitochondrial O2•¯ production was measured by electron paramagnetic resonance using DMPO spin trap. Cytochrome c levels were measured using high-pressure liquid chromatography. Results IPC preserved mΔΨ at End I (−156 ± 5 versus −131 ± 6 mV, P < 0.001) and End RP (−168 ± 2 versus −155 ± 2 mV, P < 0.05). At End RP, IPC attenuated O2•¯ production (2527 ± 221 versus 3523 ± 250 AU/mg protein, P < 0.05). IPC preserved cytochrome c levels (351 ± 14 versus 269 ± 16 picomoles/mg protein, P < 0.05) at End RP, and decreased mitochondrial cristae disruption (10% ± 4% versus 33% ± 7%, P < 0.05) and amorphous density formation (18% ± 4% versus 28% ± 1%, P < 0.05). Conclusion We conclude that IPC preserves mΔΨ, possibly by limiting disruption of mitochondrial inner membrane. IPC also decreases mitochondrial O2•¯ production and preserves mitochondrial ultrastructure after IR. While it was previously held that slight decreases in mΔΨ decrease O2•¯ production, our results indicate that preservation of mΔΨ is associated with decreased O2•¯ and preservation of cardiac function in IPC. These findings indicate that the mechanism of IPC may not involve mΔΨ depolarization, but rather preservation of mitochondrial electrochemical potential." @default.
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• W2026487669 date "2012-11-01" @default.
• W2026487669 modified "2023-10-18" @default.
• W2026487669 title "Ischemic preconditioning preserves mitochondrial membrane potential and limits reactive oxygen species production" @default.
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• W2026487669 doi "https://doi.org/10.1016/j.jss.2012.05.090" @default.
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