FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026487673> ?p ?o ?g. }

• W2026487673 endingPage "293" @default.
• W2026487673 startingPage "282" @default.
• W2026487673 abstract "It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen receptor-α (ERα) and the membrane receptor G-protein-coupled receptor 30 (GPR30) and is abrogated in the absence of B cells and the co-inhibitory receptor, Programmed Death-1 (PD-1). To critically evaluate the cell source of the E2 and PD-1 co-inhibitory pathways in EAE regulation, we assessed the requirement for ERs on transferred B cells and downstream effects on expression of PD-1/PD-ligand on CD4+ Foxp3+ regulatory T (Treg) cells in B-cell-replenished, E2-treated B-cell-deficient (μMT-/-) mice with EAE. The results clearly demonstrated involvement of ERα and GPR30 on transferred B cells that mediated the protective E2 treatment effect on EAE and further showed an E2-mediated B-cell-dependent up-regulation of PD-1 on CD4+ Foxp3+ Treg cells. These findings identify regulatory B-cell populations as key players in potentiating Treg-cell activity during E2-mediated protection against EAE." @default.
• W2026487673 created "2016-06-24" @default.
• W2026487673 creator A5004052621 @default.
• W2026487673 creator A5049571127 @default.
• W2026487673 creator A5087867695 @default.
• W2026487673 date "2012-11-20" @default.
• W2026487673 modified "2023-10-17" @default.
• W2026487673 title "Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β-oestradiol-receptor-positive B cells that up-regulate PD-1 on CD4⁺ Foxp3⁺regulatory T cells" @default.
• W2026487673 cites W1646288869 @default.
• W2026487673 cites W1714360375 @default.
• W2026487673 cites W1907155709 @default.
• W2026487673 cites W1972447650 @default.
• W2026487673 cites W1989317027 @default.
• W2026487673 cites W2007276510 @default.
• W2026487673 cites W2016279533 @default.
• W2026487673 cites W2017841541 @default.
• W2026487673 cites W2022072580 @default.
• W2026487673 cites W2024008300 @default.
• W2026487673 cites W2025825648 @default.
• W2026487673 cites W2054568941 @default.
• W2026487673 cites W2072325998 @default.
• W2026487673 cites W2075634464 @default.
• W2026487673 cites W2088783992 @default.
• W2026487673 cites W2091805754 @default.
• W2026487673 cites W2106115061 @default.
• W2026487673 cites W2114040130 @default.
• W2026487673 cites W2131958114 @default.
• W2026487673 cites W2135551891 @default.
• W2026487673 cites W2136845512 @default.
• W2026487673 cites W2138622901 @default.
• W2026487673 cites W2157275878 @default.
• W2026487673 cites W2168655254 @default.
• W2026487673 cites W2173694857 @default.
• W2026487673 cites W2319459971 @default.
• W2026487673 doi "https://doi.org/10.1111/imm.12013" @default.
• W2026487673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3530084" @default.
• W2026487673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23039230" @default.
• W2026487673 hasPublicationYear "2012" @default.
• W2026487673 type Work @default.
• W2026487673 sameAs 2026487673 @default.
• W2026487673 citedByCount "46" @default.
• W2026487673 countsByYear W20264876732013 @default.
• W2026487673 countsByYear W20264876732014 @default.
• W2026487673 countsByYear W20264876732015 @default.
• W2026487673 countsByYear W20264876732016 @default.
• W2026487673 countsByYear W20264876732017 @default.
• W2026487673 countsByYear W20264876732018 @default.
• W2026487673 countsByYear W20264876732019 @default.
• W2026487673 countsByYear W20264876732020 @default.
• W2026487673 countsByYear W20264876732021 @default.
• W2026487673 countsByYear W20264876732022 @default.
• W2026487673 crossrefType "journal-article" @default.
• W2026487673 hasAuthorship W2026487673A5004052621 @default.
• W2026487673 hasAuthorship W2026487673A5049571127 @default.
• W2026487673 hasAuthorship W2026487673A5087867695 @default.
• W2026487673 hasBestOaLocation W20264876731 @default.
• W2026487673 hasConcept C121608353 @default.
• W2026487673 hasConcept C126322002 @default.
• W2026487673 hasConcept C134018914 @default.
• W2026487673 hasConcept C1491633281 @default.
• W2026487673 hasConcept C159654299 @default.
• W2026487673 hasConcept C166471694 @default.
• W2026487673 hasConcept C170493617 @default.
• W2026487673 hasConcept C185592680 @default.
• W2026487673 hasConcept C203014093 @default.
• W2026487673 hasConcept C2777899865 @default.
• W2026487673 hasConcept C2778453870 @default.
• W2026487673 hasConcept C2778486448 @default.
• W2026487673 hasConcept C2779727006 @default.
• W2026487673 hasConcept C2780640218 @default.
• W2026487673 hasConcept C530470458 @default.
• W2026487673 hasConcept C55493867 @default.
• W2026487673 hasConcept C71924100 @default.
• W2026487673 hasConcept C84606932 @default.
• W2026487673 hasConcept C86803240 @default.
• W2026487673 hasConcept C8891405 @default.
• W2026487673 hasConcept C95444343 @default.
• W2026487673 hasConceptScore W2026487673C121608353 @default.
• W2026487673 hasConceptScore W2026487673C126322002 @default.
• W2026487673 hasConceptScore W2026487673C134018914 @default.
• W2026487673 hasConceptScore W2026487673C1491633281 @default.
• W2026487673 hasConceptScore W2026487673C159654299 @default.
• W2026487673 hasConceptScore W2026487673C166471694 @default.
• W2026487673 hasConceptScore W2026487673C170493617 @default.
• W2026487673 hasConceptScore W2026487673C185592680 @default.
• W2026487673 hasConceptScore W2026487673C203014093 @default.
• W2026487673 hasConceptScore W2026487673C2777899865 @default.
• W2026487673 hasConceptScore W2026487673C2778453870 @default.
• W2026487673 hasConceptScore W2026487673C2778486448 @default.
• W2026487673 hasConceptScore W2026487673C2779727006 @default.
• W2026487673 hasConceptScore W2026487673C2780640218 @default.
• W2026487673 hasConceptScore W2026487673C530470458 @default.
• W2026487673 hasConceptScore W2026487673C55493867 @default.
• W2026487673 hasConceptScore W2026487673C71924100 @default.
• W2026487673 hasConceptScore W2026487673C84606932 @default.
• W2026487673 hasConceptScore W2026487673C86803240 @default.
• W2026487673 hasConceptScore W2026487673C8891405 @default.
• W2026487673 hasConceptScore W2026487673C95444343 @default.

• next