FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026488085> ?p ?o ?g. }

• W2026488085 endingPage "1123" @default.
• W2026488085 startingPage "1116" @default.
• W2026488085 abstract "The lymphatic system plays important roles not only in the physiological processes, such as maintenance of tissue fluid homeostasis, but also in pathological processes including the lymph node metastasis of tumor cells. Therefore, understanding of the molecular mechanisms underlying lymphatic vessel formation is crucial. Previous studies have shown that proliferation and migration of lymphatic endothelial cells (LECs) are activated by multiple types of signals mediated by tyrosine kinase receptors such as vascular endothelial growth factor receptor (VEGFR) 3. Although signals mediated by platelet-derived growth factor receptor β (PDGFRβ) have been implicated in lymphangiogenesis, the mechanisms explaining how PDGFRβ expression is maintained in LECs remain to be fully elucidated. In the present study, we show that PDGFRβ expression in LECs is maintained by Prox1 transcription factor. Knockdown of Prox1 expression in human dermal LECs decreased the expression of PDGFRβ, leading to the lowered migration of human dermal LECs towards PDGF-BB. Furthermore, we found that PDGF signals play important roles in inflammatory lymphangiogenesis in a chronic aseptic peritonitis model. Intraperitoneal administration of imatinib, a potent inhibitor of PDGFRβ, and transduction of PDGFRβ/Fc chimeric protein by an adenoviral system both reduced inflammatory lymphangiogenesis induced by thioglycollate in mice. We also found that the expression of PDGFRβ/Fc reduced tumor lymphangiogenesis in a BxPC3 human pancreatic cancer xenograft model. These findings suggest that PDGFRβ is one of the key mediators of lymphatic vessel formation acting downstream of Prox1." @default.
• W2026488085 created "2016-06-24" @default.
• W2026488085 creator A5005708651 @default.
• W2026488085 creator A5009782150 @default.
• W2026488085 creator A5023072572 @default.
• W2026488085 creator A5027873799 @default.
• W2026488085 creator A5048426787 @default.
• W2026488085 creator A5051009186 @default.
• W2026488085 creator A5082105510 @default.
• W2026488085 date "2014-09-01" @default.
• W2026488085 modified "2023-10-04" @default.
• W2026488085 title "Expression of platelet‐derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis" @default.
• W2026488085 cites W1980705179 @default.
• W2026488085 cites W1991298929 @default.
• W2026488085 cites W1994638693 @default.
• W2026488085 cites W1996863429 @default.
• W2026488085 cites W2006642493 @default.
• W2026488085 cites W2007747524 @default.
• W2026488085 cites W2018288449 @default.
• W2026488085 cites W2037111838 @default.
• W2026488085 cites W2037590098 @default.
• W2026488085 cites W2045498383 @default.
• W2026488085 cites W2049184800 @default.
• W2026488085 cites W2065957571 @default.
• W2026488085 cites W2071766377 @default.
• W2026488085 cites W2090004346 @default.
• W2026488085 cites W2092619818 @default.
• W2026488085 cites W2096608993 @default.
• W2026488085 cites W2097731330 @default.
• W2026488085 cites W2106607260 @default.
• W2026488085 cites W2107105080 @default.
• W2026488085 cites W2113265524 @default.
• W2026488085 cites W2113355655 @default.
• W2026488085 cites W2117743783 @default.
• W2026488085 cites W2134826583 @default.
• W2026488085 cites W2139332469 @default.
• W2026488085 cites W2145139349 @default.
• W2026488085 cites W2153484787 @default.
• W2026488085 cites W2155214429 @default.
• W2026488085 cites W2155591311 @default.
• W2026488085 doi "https://doi.org/10.1111/cas.12476" @default.
• W2026488085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4462385" @default.
• W2026488085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24981766" @default.
• W2026488085 hasPublicationYear "2014" @default.
• W2026488085 type Work @default.
• W2026488085 sameAs 2026488085 @default.
• W2026488085 citedByCount "22" @default.
• W2026488085 countsByYear W20264880852014 @default.
• W2026488085 countsByYear W20264880852015 @default.
• W2026488085 countsByYear W20264880852016 @default.
• W2026488085 countsByYear W20264880852017 @default.
• W2026488085 countsByYear W20264880852018 @default.
• W2026488085 countsByYear W20264880852019 @default.
• W2026488085 countsByYear W20264880852020 @default.
• W2026488085 countsByYear W20264880852021 @default.
• W2026488085 countsByYear W20264880852022 @default.
• W2026488085 crossrefType "journal-article" @default.
• W2026488085 hasAuthorship W2026488085A5005708651 @default.
• W2026488085 hasAuthorship W2026488085A5009782150 @default.
• W2026488085 hasAuthorship W2026488085A5023072572 @default.
• W2026488085 hasAuthorship W2026488085A5027873799 @default.
• W2026488085 hasAuthorship W2026488085A5048426787 @default.
• W2026488085 hasAuthorship W2026488085A5051009186 @default.
• W2026488085 hasAuthorship W2026488085A5082105510 @default.
• W2026488085 hasBestOaLocation W20264880851 @default.
• W2026488085 hasConcept C101544691 @default.
• W2026488085 hasConcept C103041312 @default.
• W2026488085 hasConcept C121608353 @default.
• W2026488085 hasConcept C126322002 @default.
• W2026488085 hasConcept C146285616 @default.
• W2026488085 hasConcept C167734588 @default.
• W2026488085 hasConcept C170493617 @default.
• W2026488085 hasConcept C180361614 @default.
• W2026488085 hasConcept C181152851 @default.
• W2026488085 hasConcept C203014093 @default.
• W2026488085 hasConcept C2775960820 @default.
• W2026488085 hasConcept C2776636583 @default.
• W2026488085 hasConcept C2777025900 @default.
• W2026488085 hasConcept C2779013556 @default.
• W2026488085 hasConcept C2781294074 @default.
• W2026488085 hasConcept C2910366181 @default.
• W2026488085 hasConcept C502942594 @default.
• W2026488085 hasConcept C62478195 @default.
• W2026488085 hasConcept C71924100 @default.
• W2026488085 hasConcept C86803240 @default.
• W2026488085 hasConcept C95444343 @default.
• W2026488085 hasConceptScore W2026488085C101544691 @default.
• W2026488085 hasConceptScore W2026488085C103041312 @default.
• W2026488085 hasConceptScore W2026488085C121608353 @default.
• W2026488085 hasConceptScore W2026488085C126322002 @default.
• W2026488085 hasConceptScore W2026488085C146285616 @default.
• W2026488085 hasConceptScore W2026488085C167734588 @default.
• W2026488085 hasConceptScore W2026488085C170493617 @default.
• W2026488085 hasConceptScore W2026488085C180361614 @default.
• W2026488085 hasConceptScore W2026488085C181152851 @default.
• W2026488085 hasConceptScore W2026488085C203014093 @default.
• W2026488085 hasConceptScore W2026488085C2775960820 @default.
• W2026488085 hasConceptScore W2026488085C2776636583 @default.

• next