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- W2026490005 abstract "The inhibition of mTOR promotes immune tolerance in mouse models of transplantation, by favoring the expansion of regulatory T cells over effector T cells. However, attempts at inducing immune tolerance with the mTOR inhibitor (mTOR-I) in humans have so far failed. We herein review the immunological obstacles that need to be overcome in order to translate mTOR-I-related tolerogenic properties into the clinic.Our knowledge of regulatory T-cell biology has exploded over the past few years, providing clues to explain the complex impact of prolonged mTOR inhibition on the biology of regulatory T cells. Furthermore, recent data have shed light on the unexpected pro-inflammatory burst observed in some transplant recipients treated with mTOR-I. We propose that the exposure of an organism to pathogens determines the immunodominant effect of mTOR-I, altering the immune system from a state of tolerance in inbred animals to a state of infection-triggered enhanced inflammation in humans.Recent advances in the understanding of the pleiotropic effects of mTOR-I on the immune system are paving the way to new therapeutic avenues. Future mTOR-I-based tolerogenic protocols should counter the mTOR-I-related inflammation in order to selectively promote expansion of stable regulatory T cells. We herein envisage promising therapeutic perspectives." @default.
- W2026490005 created "2016-06-24" @default.
- W2026490005 creator A5004808798 @default.
- W2026490005 creator A5055749187 @default.
- W2026490005 creator A5062304111 @default.
- W2026490005 creator A5088509972 @default.
- W2026490005 date "2011-12-01" @default.
- W2026490005 modified "2023-10-05" @default.
- W2026490005 title "Harnessing regulatory T cells for transplant tolerance in the clinic through mTOR inhibition" @default.
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- W2026490005 doi "https://doi.org/10.1097/mot.0b013e32834c237a" @default.
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- W2026490005 hasPublicationYear "2011" @default.
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