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- W2026492037 abstract "Spontaneous natural killer (NK) cell activity and NK-induced cytotoxicity after interferon-γ (IFN-γ) were measured in healthy elderly subjects and in patients with senile dementia of Alzheimer type (SDAT) and multi-infarct dementia (MID). Normal basal and IFN-γ-stimulated NK cytotoxicity were found in healthy old subjects and in patients with MID. On the contrary higher NK cytotoxicity after IFN-γ (650 IU) was demonstrated in SDAT patients than in MID and healthy subjects (p < 0.001). A significant inverse correlation between the percent increase of NK cytotoxicity after IFN-γ and the Mini Mental State Examination score (p < 0.001) was also demonstrated in patients with SDAT. Our data might suggest a cytokine-dependent mechanism of NK activation in SDAT associated with the neuroimmune hypothesis of the disease." @default.
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- W2026492037 date "1997-01-01" @default.
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- W2026492037 title "Excitatory Pattern of Gamma-Interferon on Natural Killer Cell Activity in Senile Dementia of the Alzheimer Type" @default.
- W2026492037 doi "https://doi.org/10.1159/000106648" @default.
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