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- W2026492182 abstract "To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia.Tumor tissues from 68 gastric cancer patients (GC) were analyzed, and the expression of CCL2 and hypoxia-inducible factor 1 alpha (HIF-1α) in tumor tissues was detected by immunohistochemistry. Statistical evaluations that were used included univariate log-rank tests of Kaplan-Meier curves and multivariate Cox regression model analysis.CCL2 was highly expressed in 66.2% (45/68) of gastric cancer specimens. The distribution of CCL2 expression in tumor tissue was consistent with that of HIF-1α. Patients with high CCL2 expression in GC had a lower overall survival rate [50.6 mo (95%CI: 44.44-56.93) vs 64.6 mo (95%CI: 60.27-68.94), P = 0.013].CCL2 expression correlates closely with HIF-1α expression in gastric cancer. CCL2 may be an independent prognostic marker for GC." @default.
- W2026492182 created "2016-06-24" @default.
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- W2026492182 date "2014-01-01" @default.
- W2026492182 modified "2023-09-24" @default.
- W2026492182 title "Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia" @default.
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- W2026492182 doi "https://doi.org/10.3748/wjg.v20.i15.4421" @default.
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