FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026495269> ?p ?o ?g. }

• W2026495269 endingPage "341" @default.
• W2026495269 startingPage "335" @default.
• W2026495269 abstract "In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function among middle-aged and elderly men. We performed a cross-sectional study of subjects who participated between 1991 and 1995 in the Department of Veterans Affairs Normative Aging Study. Information on blood lead levels, bone lead levels (measured by K-shell X-ray fluorescence), serum uric acid, serum creatinine, estimated creatinine clearance, and ALAD polymorphism status was available in 709 subjects. Regression models were constructed to examine the relationships of serum uric acid, serum creatinine, and estimated creatinine clearance to blood or bone lead level, stratified by genotype. We also adjusted for age, body mass index, blood pressure, smoking, alcohol consumption, and ingestion of analgesic medications (n = 638). Of the 709 subjects, 7 (1%) and 107 (15%) were homozygous and heterozygous for the variant (ALAD-2) allele, respectively. The mean (range) serum uric acid and creatinine levels were 6.5 (2.9-10.6) and 1.2 (0.6-2.5) mg/dL. No significant differences were found in serum uric acid, serum creatinine, or estimated creatinine clearance by ALAD genotype. However, after adjusting for other potential confounders, we found a significant linear relationship between serum uric acid and patella bone lead (p = 0.040) among the ALAD 1-2/2-2 genotype individuals above a threshold patellar lead level of 15 micro g/g. In contrast, among the wild-type (ALAD 1-1) individuals, there was a suggestion of a significant linear relationship of serum uric acid with patella bone lead (p = 0.141), but only after a threshold of 101 micro g/g. There was evidence of a significant (p = 0.025) interaction of tibia lead with genotype (ALAD 1-1 vs. ALAD 1-2/2-2) regarding serum creatinine as an outcome, but in the same linear regression model tibia lead alone was not a significant predictor of serum creatinine. Conversely, for estimated creatinine clearance, patella lead, but not the interaction of patella lead with genotype, was a significantly independent predictor (p = 0.026). Our findings suggest that ALAD genotype may modify the effect of lead on the renal excretion of uric acid as well as overall renal function among middle-aged and elderly men who had community (nonoccupational) exposures to lead. Additional research is needed to ascertain whether this constitutes a true gene-environment interaction and, if so, its clinical impact." @default.
• W2026495269 created "2016-06-24" @default.
• W2026495269 creator A5046557560 @default.
• W2026495269 creator A5050569417 @default.
• W2026495269 creator A5056912122 @default.
• W2026495269 creator A5073763243 @default.
• W2026495269 creator A5077227129 @default.
• W2026495269 creator A5078987114 @default.
• W2026495269 date "2003-03-01" @default.
• W2026495269 modified "2023-10-16" @default.
• W2026495269 title "A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study." @default.
• W2026495269 cites W111140859 @default.
• W2026495269 cites W153354062 @default.
• W2026495269 cites W1550111394 @default.
• W2026495269 cites W1975920835 @default.
• W2026495269 cites W1984193507 @default.
• W2026495269 cites W1993637822 @default.
• W2026495269 cites W1994203390 @default.
• W2026495269 cites W2007639535 @default.
• W2026495269 cites W2026055695 @default.
• W2026495269 cites W2036029760 @default.
• W2026495269 cites W2037494394 @default.
• W2026495269 cites W2040262552 @default.
• W2026495269 cites W2040757584 @default.
• W2026495269 cites W2060054451 @default.
• W2026495269 cites W2062112600 @default.
• W2026495269 cites W2062776508 @default.
• W2026495269 cites W2065620978 @default.
• W2026495269 cites W2068224930 @default.
• W2026495269 cites W2071258482 @default.
• W2026495269 cites W2073768442 @default.
• W2026495269 cites W2089928457 @default.
• W2026495269 cites W2115526102 @default.
• W2026495269 cites W2142695526 @default.
• W2026495269 cites W2146183639 @default.
• W2026495269 cites W2281708637 @default.
• W2026495269 cites W2335420984 @default.
• W2026495269 cites W2342953403 @default.
• W2026495269 cites W262853754 @default.
• W2026495269 doi "https://doi.org/10.1289/ehp.5504" @default.
• W2026495269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1241391" @default.
• W2026495269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12611663" @default.
• W2026495269 hasPublicationYear "2003" @default.
• W2026495269 type Work @default.
• W2026495269 sameAs 2026495269 @default.
• W2026495269 citedByCount "43" @default.
• W2026495269 countsByYear W20264952692012 @default.
• W2026495269 countsByYear W20264952692013 @default.
• W2026495269 countsByYear W20264952692014 @default.
• W2026495269 countsByYear W20264952692015 @default.
• W2026495269 countsByYear W20264952692017 @default.
• W2026495269 countsByYear W20264952692019 @default.
• W2026495269 countsByYear W20264952692020 @default.
• W2026495269 countsByYear W20264952692021 @default.
• W2026495269 countsByYear W20264952692023 @default.
• W2026495269 crossrefType "journal-article" @default.
• W2026495269 hasAuthorship W2026495269A5046557560 @default.
• W2026495269 hasAuthorship W2026495269A5050569417 @default.
• W2026495269 hasAuthorship W2026495269A5056912122 @default.
• W2026495269 hasAuthorship W2026495269A5073763243 @default.
• W2026495269 hasAuthorship W2026495269A5077227129 @default.
• W2026495269 hasAuthorship W2026495269A5078987114 @default.
• W2026495269 hasBestOaLocation W20264952691 @default.
• W2026495269 hasConcept C104317684 @default.
• W2026495269 hasConcept C126322002 @default.
• W2026495269 hasConcept C134018914 @default.
• W2026495269 hasConcept C135763542 @default.
• W2026495269 hasConcept C159641895 @default.
• W2026495269 hasConcept C185592680 @default.
• W2026495269 hasConcept C2779881121 @default.
• W2026495269 hasConcept C2779896295 @default.
• W2026495269 hasConcept C2780221984 @default.
• W2026495269 hasConcept C2780306776 @default.
• W2026495269 hasConcept C55493867 @default.
• W2026495269 hasConcept C71924100 @default.
• W2026495269 hasConceptScore W2026495269C104317684 @default.
• W2026495269 hasConceptScore W2026495269C126322002 @default.
• W2026495269 hasConceptScore W2026495269C134018914 @default.
• W2026495269 hasConceptScore W2026495269C135763542 @default.
• W2026495269 hasConceptScore W2026495269C159641895 @default.
• W2026495269 hasConceptScore W2026495269C185592680 @default.
• W2026495269 hasConceptScore W2026495269C2779881121 @default.
• W2026495269 hasConceptScore W2026495269C2779896295 @default.
• W2026495269 hasConceptScore W2026495269C2780221984 @default.
• W2026495269 hasConceptScore W2026495269C2780306776 @default.
• W2026495269 hasConceptScore W2026495269C55493867 @default.
• W2026495269 hasConceptScore W2026495269C71924100 @default.
• W2026495269 hasIssue "3" @default.
• W2026495269 hasLocation W20264952691 @default.
• W2026495269 hasLocation W20264952692 @default.
• W2026495269 hasLocation W20264952693 @default.
• W2026495269 hasLocation W20264952694 @default.
• W2026495269 hasLocation W20264952695 @default.
• W2026495269 hasOpenAccess W2026495269 @default.
• W2026495269 hasPrimaryLocation W20264952691 @default.
• W2026495269 hasRelatedWork W150763949 @default.
• W2026495269 hasRelatedWork W1964687904 @default.
• W2026495269 hasRelatedWork W1969445091 @default.

• next