Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026495855> ?p ?o ?g. }
- W2026495855 endingPage "104" @default.
- W2026495855 startingPage "96" @default.
- W2026495855 abstract "Thyroid hormones (THs) are crucial elements in vertebrate brain development. They exert their action mainly through binding of 3,5,3'-triiodothyronine (T3) to nuclear receptors that directly influence the expression of TH-regulated genes. Intracellular TH action is therefore dependent on both the availability of T3 and its receptors. TH uptake in cells is regulated by specific TH transporters and local activation and inactivation is regulated by deiodinases. This review provides an overview of the general expression pattern of TH transporters, deiodinases and receptors during embryonic chicken brain development and compares it to the situation in mammals. It is clear that THs and their regulators are present in the embryonic brain from the early stages of development, long before the onset of embryonic thyroid gland functioning. The mechanism of TH uptake across the brain barriers during development is only partly understood. At the developing blood-brain-barrier expression of the TH-activating type 2 deiodinase is closely associated with the blood vessels, but contrary to the situation in (adult) mammals no expression of MCT8 or OATP1C1 TH transporters is found at that level in the developing chicken. At the blood-cerebrospinal fluid-barrier co-expression of the TH-inactivating type 3 deiodinase and MCT8 and OATP1C1 is found in birds and mammals. These comparative data show overlapping patterns, pointing to general mechanisms, but also indicate specific interspecies differences that may help to understand species-specific responses to regulator gene knockout/mutation." @default.
- W2026495855 created "2016-06-24" @default.
- W2026495855 creator A5006854151 @default.
- W2026495855 creator A5048475867 @default.
- W2026495855 creator A5064913115 @default.
- W2026495855 creator A5089839083 @default.
- W2026495855 date "2013-09-01" @default.
- W2026495855 modified "2023-09-27" @default.
- W2026495855 title "Regulators of thyroid hormone availability and action in embryonic chicken brain development" @default.
- W2026495855 cites W1512446190 @default.
- W2026495855 cites W1548473231 @default.
- W2026495855 cites W1592115964 @default.
- W2026495855 cites W15943984 @default.
- W2026495855 cites W1751840608 @default.
- W2026495855 cites W1874864946 @default.
- W2026495855 cites W1926332751 @default.
- W2026495855 cites W1965743926 @default.
- W2026495855 cites W1968724289 @default.
- W2026495855 cites W1972866559 @default.
- W2026495855 cites W1972994957 @default.
- W2026495855 cites W1975345061 @default.
- W2026495855 cites W1975956491 @default.
- W2026495855 cites W1977680584 @default.
- W2026495855 cites W1978293152 @default.
- W2026495855 cites W1979030149 @default.
- W2026495855 cites W1980973383 @default.
- W2026495855 cites W1988348937 @default.
- W2026495855 cites W1988572194 @default.
- W2026495855 cites W1990430586 @default.
- W2026495855 cites W1990675136 @default.
- W2026495855 cites W1992268803 @default.
- W2026495855 cites W1992782297 @default.
- W2026495855 cites W1995526292 @default.
- W2026495855 cites W1995656567 @default.
- W2026495855 cites W1996180467 @default.
- W2026495855 cites W1996321551 @default.
- W2026495855 cites W1999977084 @default.
- W2026495855 cites W2000741536 @default.
- W2026495855 cites W2001411873 @default.
- W2026495855 cites W2001681817 @default.
- W2026495855 cites W2002197081 @default.
- W2026495855 cites W2003795436 @default.
- W2026495855 cites W2003806476 @default.
- W2026495855 cites W2005720053 @default.
- W2026495855 cites W2010817865 @default.
- W2026495855 cites W2014579000 @default.
- W2026495855 cites W2017632004 @default.
- W2026495855 cites W2021932599 @default.
- W2026495855 cites W2022349101 @default.
- W2026495855 cites W2023916352 @default.
- W2026495855 cites W2024116370 @default.
- W2026495855 cites W2024147132 @default.
- W2026495855 cites W2024822778 @default.
- W2026495855 cites W2027047554 @default.
- W2026495855 cites W2038964583 @default.
- W2026495855 cites W2041566437 @default.
- W2026495855 cites W2043055866 @default.
- W2026495855 cites W2045176405 @default.
- W2026495855 cites W2046152275 @default.
- W2026495855 cites W2052693888 @default.
- W2026495855 cites W2054764790 @default.
- W2026495855 cites W2058071696 @default.
- W2026495855 cites W2062347722 @default.
- W2026495855 cites W2063324861 @default.
- W2026495855 cites W2066837860 @default.
- W2026495855 cites W2072909169 @default.
- W2026495855 cites W2073100952 @default.
- W2026495855 cites W2073942818 @default.
- W2026495855 cites W2078333270 @default.
- W2026495855 cites W2079429834 @default.
- W2026495855 cites W2081084386 @default.
- W2026495855 cites W2082063013 @default.
- W2026495855 cites W2083714907 @default.
- W2026495855 cites W2086004667 @default.
- W2026495855 cites W2095483941 @default.
- W2026495855 cites W2096138350 @default.
- W2026495855 cites W2097440306 @default.
- W2026495855 cites W2101123075 @default.
- W2026495855 cites W2101581641 @default.
- W2026495855 cites W2102611661 @default.
- W2026495855 cites W2104894367 @default.
- W2026495855 cites W2109053894 @default.
- W2026495855 cites W2111308938 @default.
- W2026495855 cites W2113196899 @default.
- W2026495855 cites W2119818391 @default.
- W2026495855 cites W2122237405 @default.
- W2026495855 cites W2125402020 @default.
- W2026495855 cites W2127859037 @default.
- W2026495855 cites W2128933624 @default.
- W2026495855 cites W2132122521 @default.
- W2026495855 cites W2133684250 @default.
- W2026495855 cites W2151410031 @default.
- W2026495855 cites W2152791016 @default.
- W2026495855 cites W2154598101 @default.
- W2026495855 cites W2154755675 @default.
- W2026495855 cites W2155122828 @default.
- W2026495855 cites W2157186750 @default.
- W2026495855 cites W2159821105 @default.