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- W2026496072 endingPage "23" @default.
- W2026496072 startingPage "9" @default.
- W2026496072 abstract "A bstract : Death from anthrax has been reported to occur from systemic shock. The lethal toxin (LeTx) is the major effector of anthrax mortality. Although the mechanism of entry of this toxin into cells is well understood, its actions once inside the cell are not as well understood. LeTx is known to cleave and inactivate MAPKKs. We have recently shown that LeTx represses the glucocorticoid receptor (GR) both in vitro and in vivo . This repression is partial and specific, repressing the glucocorticoid, progesterone, and estrogen receptor α, but not the mineralocorticoid or estrogen receptor β. This toxin does not affect GR ligand or DNA binding, and we have suggested that it may function by removing/inactivating one or more of the many cofactors involved in nuclear hormone receptor signaling. Although the precise involvement of this nuclear hormone receptor repression in LeTx toxicity is unknown, examples of blunted HPA axis and glucocorticoid signaling in numerous autoimmune/inflammatory diseases suggest that such repression of critically important receptors could have deleterious effects on health." @default.
- W2026496072 created "2016-06-24" @default.
- W2026496072 creator A5004197275 @default.
- W2026496072 creator A5007193647 @default.
- W2026496072 creator A5078283465 @default.
- W2026496072 date "2004-06-01" @default.
- W2026496072 modified "2023-10-16" @default.
- W2026496072 title "Novel Repression of the Glucocorticoid Receptor by Anthrax Lethal Toxin" @default.
- W2026496072 cites W1485545593 @default.
- W2026496072 cites W1517035469 @default.
- W2026496072 cites W1536607091 @default.
- W2026496072 cites W1552850613 @default.
- W2026496072 cites W1584384268 @default.
- W2026496072 cites W1718876362 @default.
- W2026496072 cites W1842440437 @default.
- W2026496072 cites W1864493807 @default.
- W2026496072 cites W1894250052 @default.
- W2026496072 cites W1902591105 @default.
- W2026496072 cites W1906629914 @default.
- W2026496072 cites W1919133853 @default.
- W2026496072 cites W1967488188 @default.
- W2026496072 cites W1967693935 @default.
- W2026496072 cites W1972127899 @default.
- W2026496072 cites W1973208298 @default.
- W2026496072 cites W1974516704 @default.
- W2026496072 cites W1976548850 @default.
- W2026496072 cites W1980722886 @default.
- W2026496072 cites W1982105713 @default.
- W2026496072 cites W1982453454 @default.
- W2026496072 cites W1982931293 @default.
- W2026496072 cites W1986999855 @default.
- W2026496072 cites W1990121258 @default.
- W2026496072 cites W1991934048 @default.
- W2026496072 cites W1995910871 @default.
- W2026496072 cites W1997510672 @default.
- W2026496072 cites W1998304198 @default.
- W2026496072 cites W1998405496 @default.
- W2026496072 cites W1999781970 @default.
- W2026496072 cites W2001301879 @default.
- W2026496072 cites W2002521426 @default.
- W2026496072 cites W2004673387 @default.
- W2026496072 cites W2004693684 @default.
- W2026496072 cites W2005219438 @default.
- W2026496072 cites W2007771911 @default.
- W2026496072 cites W2007792232 @default.
- W2026496072 cites W2008588998 @default.
- W2026496072 cites W2013087654 @default.
- W2026496072 cites W2013286012 @default.
- W2026496072 cites W2013667866 @default.
- W2026496072 cites W2015611430 @default.
- W2026496072 cites W2018506593 @default.
- W2026496072 cites W2018934334 @default.
- W2026496072 cites W2021146420 @default.
- W2026496072 cites W2021943148 @default.
- W2026496072 cites W2029260651 @default.
- W2026496072 cites W2029460667 @default.
- W2026496072 cites W2040911419 @default.
- W2026496072 cites W2041535822 @default.
- W2026496072 cites W2042682065 @default.
- W2026496072 cites W2046583364 @default.
- W2026496072 cites W2048445979 @default.
- W2026496072 cites W2052001310 @default.
- W2026496072 cites W2052175404 @default.
- W2026496072 cites W2052264640 @default.
- W2026496072 cites W2054027422 @default.
- W2026496072 cites W2055654988 @default.
- W2026496072 cites W2055904441 @default.
- W2026496072 cites W2056763517 @default.
- W2026496072 cites W2060037483 @default.
- W2026496072 cites W2064776404 @default.
- W2026496072 cites W2065686737 @default.
- W2026496072 cites W2067547922 @default.
- W2026496072 cites W2068246413 @default.
- W2026496072 cites W2068804236 @default.
- W2026496072 cites W2071536052 @default.
- W2026496072 cites W2073038487 @default.
- W2026496072 cites W2073103427 @default.
- W2026496072 cites W2074843227 @default.
- W2026496072 cites W2075964433 @default.
- W2026496072 cites W2076018386 @default.
- W2026496072 cites W2078046763 @default.
- W2026496072 cites W2078433837 @default.
- W2026496072 cites W2078514099 @default.
- W2026496072 cites W2082755088 @default.
- W2026496072 cites W2083670089 @default.
- W2026496072 cites W2083703681 @default.
- W2026496072 cites W2085124463 @default.
- W2026496072 cites W2086195938 @default.
- W2026496072 cites W2087018371 @default.
- W2026496072 cites W2090424379 @default.
- W2026496072 cites W2092172599 @default.
- W2026496072 cites W2098266959 @default.
- W2026496072 cites W2101355256 @default.
- W2026496072 cites W2101754579 @default.
- W2026496072 cites W2105235564 @default.
- W2026496072 cites W2105680347 @default.
- W2026496072 cites W2109288083 @default.
- W2026496072 cites W2110325790 @default.