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• W2026504935 abstract "Androgen receptor (AR) is an attractive target for the treatment of prostate cancer. An integrated pharmacophore-based and docking-based virtual screening approach was applied to identify novel AR antagonists with a distinct scaffold. The candidate compounds were evaluated for their abilities to inhibit prostate cancer cell proliferation and AR target gene prostate-specific antigen gene expression as well as the binding affinity to AR. A potent lead compound, T3, was discovered with the ability to inhibit prostate-specific antigen expression, with a similar binding affinity to AR, and with antiproliferative effects on AR-positive prostate cancer cells similar to that of MDV3100." @default.
• W2026504935 created "2016-06-24" @default.
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• W2026504935 date "2015-08-01" @default.
• W2026504935 modified "2023-09-22" @default.
• W2026504935 title "Discovery of novel androgen receptor antagonists" @default.
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• W2026504935 doi "https://doi.org/10.1097/cad.0000000000000245" @default.
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