Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026512497> ?p ?o ?g. }
- W2026512497 endingPage "4136" @default.
- W2026512497 startingPage "4131" @default.
- W2026512497 abstract "Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control. We produced TRX overexpressing mice and confirmed that there were no anatomical and physiological differences between wild-type (WT) mice and TRX transgenic (Tg) mice. In the present study we subjected mice to focal brain ischemia to shed light on the role of TRX in brain ischemic injury. At 24 hr after middle cerebral artery occlusion, infarct areas and volume were significantly smaller in Tg mice than in WT mice. Moreover neurological deficit was ameliorated in Tg mice compared with WT mice. Protein carbonyl content, a marker of cellular protein oxidation, in Tg mice showed less increase than did that of WT mice after the ischemic insult. Furthermore, c-fos expression in Tg mice was stronger than in WT mice 1 hr after ischemia. Our results suggest that transgene expression of TRX decreased ischemic neuronal injury and that TRX and the redox state modified by TRX play a crucial role in brain damage during stroke." @default.
- W2026512497 created "2016-06-24" @default.
- W2026512497 creator A5001222038 @default.
- W2026512497 creator A5013359396 @default.
- W2026512497 creator A5045027100 @default.
- W2026512497 creator A5049861668 @default.
- W2026512497 creator A5069470838 @default.
- W2026512497 creator A5072897776 @default.
- W2026512497 creator A5074602663 @default.
- W2026512497 creator A5087002449 @default.
- W2026512497 date "1999-03-30" @default.
- W2026512497 modified "2023-10-17" @default.
- W2026512497 title "Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage" @default.
- W2026512497 cites W1555938743 @default.
- W2026512497 cites W1577403013 @default.
- W2026512497 cites W1842535138 @default.
- W2026512497 cites W1858934288 @default.
- W2026512497 cites W1965766555 @default.
- W2026512497 cites W1969268163 @default.
- W2026512497 cites W1971076522 @default.
- W2026512497 cites W1975077455 @default.
- W2026512497 cites W1976467696 @default.
- W2026512497 cites W1978070416 @default.
- W2026512497 cites W1978690847 @default.
- W2026512497 cites W1984389527 @default.
- W2026512497 cites W1987939219 @default.
- W2026512497 cites W1988825841 @default.
- W2026512497 cites W1988951836 @default.
- W2026512497 cites W2016575029 @default.
- W2026512497 cites W2017598913 @default.
- W2026512497 cites W2018192576 @default.
- W2026512497 cites W2020303700 @default.
- W2026512497 cites W2025833711 @default.
- W2026512497 cites W2033828028 @default.
- W2026512497 cites W2034691729 @default.
- W2026512497 cites W2040071780 @default.
- W2026512497 cites W2041176993 @default.
- W2026512497 cites W2043211556 @default.
- W2026512497 cites W2045899523 @default.
- W2026512497 cites W2047480541 @default.
- W2026512497 cites W2053291096 @default.
- W2026512497 cites W2058346110 @default.
- W2026512497 cites W2059383335 @default.
- W2026512497 cites W2062502290 @default.
- W2026512497 cites W2064280448 @default.
- W2026512497 cites W2065264404 @default.
- W2026512497 cites W2067072091 @default.
- W2026512497 cites W2070693959 @default.
- W2026512497 cites W2073383715 @default.
- W2026512497 cites W2074187719 @default.
- W2026512497 cites W2076698695 @default.
- W2026512497 cites W2081436603 @default.
- W2026512497 cites W2085459880 @default.
- W2026512497 cites W2087292928 @default.
- W2026512497 cites W2087747956 @default.
- W2026512497 cites W2088155527 @default.
- W2026512497 cites W2104532925 @default.
- W2026512497 cites W2112505121 @default.
- W2026512497 cites W2116337084 @default.
- W2026512497 cites W2123791869 @default.
- W2026512497 cites W2136002830 @default.
- W2026512497 cites W2137847377 @default.
- W2026512497 cites W2142944900 @default.
- W2026512497 cites W2143007633 @default.
- W2026512497 cites W2147961849 @default.
- W2026512497 cites W2153524858 @default.
- W2026512497 cites W2156118426 @default.
- W2026512497 cites W2156156911 @default.
- W2026512497 cites W2161222674 @default.
- W2026512497 cites W2240454133 @default.
- W2026512497 cites W2330163361 @default.
- W2026512497 cites W2419010349 @default.
- W2026512497 cites W4247896860 @default.
- W2026512497 doi "https://doi.org/10.1073/pnas.96.7.4131" @default.
- W2026512497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22432" @default.
- W2026512497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10097175" @default.
- W2026512497 hasPublicationYear "1999" @default.
- W2026512497 type Work @default.
- W2026512497 sameAs 2026512497 @default.
- W2026512497 citedByCount "324" @default.
- W2026512497 countsByYear W20265124972012 @default.
- W2026512497 countsByYear W20265124972013 @default.
- W2026512497 countsByYear W20265124972014 @default.
- W2026512497 countsByYear W20265124972015 @default.
- W2026512497 countsByYear W20265124972016 @default.
- W2026512497 countsByYear W20265124972017 @default.
- W2026512497 countsByYear W20265124972018 @default.
- W2026512497 countsByYear W20265124972019 @default.
- W2026512497 countsByYear W20265124972020 @default.
- W2026512497 countsByYear W20265124972021 @default.
- W2026512497 countsByYear W20265124972022 @default.
- W2026512497 countsByYear W20265124972023 @default.
- W2026512497 crossrefType "journal-article" @default.
- W2026512497 hasAuthorship W2026512497A5001222038 @default.
- W2026512497 hasAuthorship W2026512497A5013359396 @default.
- W2026512497 hasAuthorship W2026512497A5045027100 @default.
- W2026512497 hasAuthorship W2026512497A5049861668 @default.
- W2026512497 hasAuthorship W2026512497A5069470838 @default.