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• W2026533906 abstract "Abstract The mechanism of action of chick interferon was studied by the use of cell-free extracts of interferon-treated and mock-interferon-treated primary chick embryo cells. These cell-free extracts differed from those of chick origin which have been used previously in that they did not require supplementation with heterologous factor preparations. In extracts of cells which had been pretreated with mock preparations of interferon, purified vesicular stomatitis virus (VSV) directed the coupled transcription and translation of the viral genes. In extracts of interferon-treated cells, viral transcription was not inhibited, but the rate of translation was reduced by up to 70%, the extent of inhibition being dependent upon the interferon dose. The translation inhibition was not consistently reversed by the addition of chick cell transfer RNA, but was consistently accentuated in the presence of low concentrations of double-stranded RNA. To explore the possibility that this inhibition of protein synthesis was due to an effect on viral messenger RNA synthesis or processing, the products of VSV transcription in the two systems were compared for: (i) their size distribution, by polyacrylamide-gel electrophoresis under denaturing conditions; (ii) their stability, by UTP pulse-chase methods; (iii) their degree of polyadenylation, by oligo(dT)-cellulose column chromatography; (iv) their degree of methylation, by S-adenosyl[ methyl - 3 H]methionine/[ 14 C]UTP double-labeling; and (v) their ability to be translated upon reintroduction into cell-free systems from mock- or interferon-treated chick cells. These tests showed no difference between the preparations of viral mRNA made in the two systems, which indicated that translation itself was the site of inhibition under these conditions. Consistent with this conclusion was the fact that the translation of other messenger RNAs of both viral and animal cell origin was inhibited to a similar extent." @default.
• W2026533906 created "2016-06-24" @default.
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• W2026533906 date "1978-02-01" @default.
• W2026533906 modified "2023-09-25" @default.
• W2026533906 title "Effect of interferon pretreatment on coupled transcription and translation in cell-free extracts of primary chick embryo cells" @default.
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• W2026533906 doi "https://doi.org/10.1016/0042-6822(78)90265-9" @default.
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