FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026534022> ?p ?o ?g. }

• W2026534022 endingPage "418" @default.
• W2026534022 startingPage "408" @default.
• W2026534022 abstract "Abstract Cyclic acetal hydrogels are a novel group of biomaterials which may facilitate osteogenic differentiation of encapsulated bone marrow stromal cells (BMSCs) because of their neutral degradation products. Here, we have incorporated hydroxyapatite nanoparticles within cyclic acetal hydrogels to create cyclic acetal nanocomposites for craniofacial tissue engineering applications. We hypothesized that inclusion of nanosized hydroxyapatite particles within cyclic acetal hydrogels would upregulate osteogenic signal expression of encapsulated BMSCs, due to enhanced cell adhesion, and therefore promote osteodifferentiation. Experimental nanocomposite groups consisted of lower (5 ng/mL) and higher (50 ng/mL) concentrations of nanoparticles. The nanocomposites were characterized by scanning electron microscopy, transmission electron microscopy, and energy dispersive spectroscopy. Swelling parameters of hydrogels in the presence of nanoparticles was studied. Osteoblastic differentiation was characterized by alkaline phosphatase (ALP) and osteocalcin (OC) expression, whereas endogenous osteogenic signal expression was characterized by morphogenetic protein‐2 (BMP‐2) expression. Finally, immunohistochemistry was performed to detect the presence of OC at the protein level. Results indicated that hydroxyapatite nanoparticles were uniformly distributed throughout the hydrogels and did not affect material properties of the gels. Viability of cells was not affected by nanoparticle concentration, and BMP‐2 and OC mRNA expression was enhanced in the presence of nanoparticles. However, a difference in BMP‐2, ALP, and OC mRNA expression was not noted between the lower and higher concentrations of nanoparticles. This work demonstrates that inclusion of hydroxyapatite nanoparticles within a cyclic acetal nanocomposite hydrogel may enhance BMSC differentiation by promoting endogenous osteogenic signal expression. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res 2010" @default.
• W2026534022 created "2016-06-24" @default.
• W2026534022 creator A5008191805 @default.
• W2026534022 creator A5034456496 @default.
• W2026534022 creator A5039236521 @default.
• W2026534022 creator A5040342783 @default.
• W2026534022 creator A5055125615 @default.
• W2026534022 creator A5064165519 @default.
• W2026534022 date "2010-02-22" @default.
• W2026534022 modified "2023-10-10" @default.
• W2026534022 title "Characterization of cyclic acetal hydroxyapatite nanocomposites for craniofacial tissue engineering" @default.
• W2026534022 cites W1964264991 @default.
• W2026534022 cites W1964745823 @default.
• W2026534022 cites W1970967229 @default.
• W2026534022 cites W1975897724 @default.
• W2026534022 cites W1977490791 @default.
• W2026534022 cites W1978744194 @default.
• W2026534022 cites W1979110201 @default.
• W2026534022 cites W1979621289 @default.
• W2026534022 cites W1981036688 @default.
• W2026534022 cites W1983860959 @default.
• W2026534022 cites W1986580482 @default.
• W2026534022 cites W1988266968 @default.
• W2026534022 cites W1990082231 @default.
• W2026534022 cites W1993817188 @default.
• W2026534022 cites W1995434070 @default.
• W2026534022 cites W2000157584 @default.
• W2026534022 cites W2000630219 @default.
• W2026534022 cites W2011596843 @default.
• W2026534022 cites W2016526326 @default.
• W2026534022 cites W2021790237 @default.
• W2026534022 cites W2023085572 @default.
• W2026534022 cites W2024234810 @default.
• W2026534022 cites W2029510959 @default.
• W2026534022 cites W2030502794 @default.
• W2026534022 cites W2033490867 @default.
• W2026534022 cites W2041772625 @default.
• W2026534022 cites W2047205118 @default.
• W2026534022 cites W2049094608 @default.
• W2026534022 cites W2049584548 @default.
• W2026534022 cites W2054024404 @default.
• W2026534022 cites W2062194570 @default.
• W2026534022 cites W2064478258 @default.
• W2026534022 cites W2067719770 @default.
• W2026534022 cites W2068812290 @default.
• W2026534022 cites W2068956931 @default.
• W2026534022 cites W2069738359 @default.
• W2026534022 cites W2071472512 @default.
• W2026534022 cites W2071533763 @default.
• W2026534022 cites W2075425296 @default.
• W2026534022 cites W2078643334 @default.
• W2026534022 cites W2081204907 @default.
• W2026534022 cites W2083585012 @default.
• W2026534022 cites W2087122586 @default.
• W2026534022 cites W2088003749 @default.
• W2026534022 cites W2088540283 @default.
• W2026534022 cites W2090071758 @default.
• W2026534022 cites W2096005599 @default.
• W2026534022 cites W2099580984 @default.
• W2026534022 cites W2100675841 @default.
• W2026534022 cites W2104289773 @default.
• W2026534022 cites W2107167949 @default.
• W2026534022 cites W2107538055 @default.
• W2026534022 cites W2115680361 @default.
• W2026534022 cites W2117866376 @default.
• W2026534022 cites W2118301071 @default.
• W2026534022 cites W2128679188 @default.
• W2026534022 cites W2146109063 @default.
• W2026534022 cites W2171727206 @default.
• W2026534022 doi "https://doi.org/10.1002/jbm.a.32683" @default.
• W2026534022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20186741" @default.
• W2026534022 hasPublicationYear "2010" @default.
• W2026534022 type Work @default.
• W2026534022 sameAs 2026534022 @default.
• W2026534022 citedByCount "8" @default.
• W2026534022 countsByYear W20265340222015 @default.
• W2026534022 countsByYear W20265340222016 @default.
• W2026534022 countsByYear W20265340222017 @default.
• W2026534022 countsByYear W20265340222019 @default.
• W2026534022 countsByYear W20265340222022 @default.
• W2026534022 crossrefType "journal-article" @default.
• W2026534022 hasAuthorship W2026534022A5008191805 @default.
• W2026534022 hasAuthorship W2026534022A5034456496 @default.
• W2026534022 hasAuthorship W2026534022A5039236521 @default.
• W2026534022 hasAuthorship W2026534022A5040342783 @default.
• W2026534022 hasAuthorship W2026534022A5055125615 @default.
• W2026534022 hasAuthorship W2026534022A5064165519 @default.
• W2026534022 hasConcept C108586683 @default.
• W2026534022 hasConcept C12554922 @default.
• W2026534022 hasConcept C127413603 @default.
• W2026534022 hasConcept C136229726 @default.
• W2026534022 hasConcept C155672457 @default.
• W2026534022 hasConcept C160160445 @default.
• W2026534022 hasConcept C171250308 @default.
• W2026534022 hasConcept C178790620 @default.
• W2026534022 hasConcept C181199279 @default.
• W2026534022 hasConcept C185592680 @default.
• W2026534022 hasConcept C188027245 @default.

• next