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- W2026534610 abstract "As a platform for making recombinant proteins, E. coli is hard to beat. This universal gut bacterium grows quickly and eagerly, and—with simple genetic tinkering—will make virtually any foreign protein. However, E. coli, a prokaryote, can't handle posttranslational modifications; the proteins it makes are often misfolded and insoluble, requiring expensive processing steps to make them usable. Mammalian cells, in contrast, fold and modify proteins with ease but are much harder to culture. One organism that potentially combines the advantages of bacterial and mammalian expression systems is Pichia pastoris, a harmless species of yeast that feeds on methanol." @default.
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- W2026534610 date "2008-03-01" @default.
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- W2026534610 title "Pichia Power: India's Biotech Industry Puts Unconventional Yeast to Work" @default.
- W2026534610 doi "https://doi.org/10.1016/j.chembiol.2008.03.002" @default.
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