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- W2026535551 abstract ":We report six fatal cases of hepatic necrosis in children associated with multiple anticonvulsant therapy. There was insufficient evidence to incriminate any single drug or combination of drugs, but it is noteworthy that sodium valproate was involved in only one case. We consider that an idiosyncratic metabolic reaction to the anticonvulsants was most likely. In five of the six cases hepatic failure was immediately preceeded by a prolonged fit and we speculate that metabolic change from excessive neuronal activity may unmask the hepatofoxicity of anticonvulsants." @default.
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- W2026535551 date "1988-06-01" @default.
- W2026535551 modified "2023-09-26" @default.
- W2026535551 title "FATAL HEPATIC NECROSIS ASSOCIATED WITH MULTIPLE ANTICONVULSANT THERAPY" @default.
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- W2026535551 doi "https://doi.org/10.1111/j.1445-5994.1988.tb00127.x" @default.
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