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• W2026547055 abstract "Rap2A, Rap2B, and Rap2C are Ras-like small G proteins. The role of their post-translational processing has not been investigated due to the lack of information on their downstream signaling. We have recently identified the Traf2- and Nck-interacting kinase (TNIK), a member of the STE20 group of mitogen-activated protein kinase kinase kinase kinases, as a specific Rap2 effector. Here we report that, in HEK293T cells, Rap2A (farnesylated) and Rap2C (likely farnesylated), but not Rap2B (geranylgeranylated), require palmitoylation for membrane-association and TNIK activation, whereas all Rap2 proteins, including Rap2B, require palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading. Furthermore, we report for the first time that, in COS-1 cells, Rap2 proteins localize, and recruit TNIK, to the recycling endosomes, but not the Golgi nor the endoplasmic reticulum, in a palmitoylation-dependent manner. These observations implicate the involvement of palmitoylation and recycling endosome localization in cellular functions of Rap2 proteins." @default.
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• W2026547055 date "2009-01-01" @default.
• W2026547055 modified "2023-10-12" @default.
• W2026547055 title "Rap2 function requires palmitoylation and recycling endosome localization" @default.
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• W2026547055 doi "https://doi.org/10.1016/j.bbrc.2008.11.107" @default.
• W2026547055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19061864" @default.
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