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- W2026558596 endingPage "130" @default.
- W2026558596 startingPage "120" @default.
- W2026558596 abstract "Improvements in our understanding of the molecular biology of cancer have shifted management of lung cancer toward molecular-guided, individualized treatment. Development of epidermal growth factor receptor tyrosine kinase inhibitors, erlotinib and gefitinib, represent the best example of this approach. Erlotinib was tested as second/third line treatment in unselected population of patients and demonstrated a statistically significant prolongation of overall survival, while gefitinib was shown to be non-inferior to docetaxel as second line treatment. The discovery of EGFR activating mutations facilitated the selection of patients most likely to benefit from erlotinib/gefitinib. These drugs in patients with EGFR activating mutations offer an increased progression free survival and significantly higher response rates compared to chemotherapy. The purpose of this paper is to present the relevant clinical data, describe the predictive markers available for TKIs treatment in NSCLC, and describe the mechanisms associated with resistance to treatment with these agents." @default.
- W2026558596 created "2016-06-24" @default.
- W2026558596 creator A5049509860 @default.
- W2026558596 creator A5083377302 @default.
- W2026558596 date "2013-05-01" @default.
- W2026558596 modified "2023-09-26" @default.
- W2026558596 title "Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC" @default.
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