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• W2026558983 abstract "The Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt signal pathway. H2O2 decreases the amount of nuclear β-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1 abrogated H2O2-induced downregulation of β-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2 negatively modulates the Wnt signal pathway through downregulation of β-catenin." @default.
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• W2026558983 date "2004-08-01" @default.
• W2026558983 modified "2023-09-23" @default.
• W2026558983 title "Hydrogen peroxide negatively modulates Wnt signaling through downregulation of β-catenin" @default.
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• W2026558983 doi "https://doi.org/10.1016/j.canlet.2004.03.003" @default.
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