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- W2026560639 abstract "Endothelins are a family of conserved vasoactive peptides that are widely expressed in different biological systems including the eye. In the cell culture model of retinal pigment epithelium, ARPE-19, the synthesis and secretion of endothelin-1 (ET-1) is regulated by cholinergics and TNF-α. In the present study we investigated the expression of ET-1 in RPE in situ, in rat and human eyes. Additionally, we have employed the human retinal pigment epithelial (ARPE-19) cells to delineate the apical and basolateral ET-1 expression and secretion by confocal microscopy and radioimmunoassay , respectively. Our results suggest a possible conservation of ET-1 expression predominantly in the mammalian RPE underlining its importance at this site. Additionally, our results suggest that constitutive ET-1 secretion is predominantly towards the basolateral side in cultured RPE possibly allowing ET-1 to activate its receptors located in the choroidal blood vessels and regulate retinal and choroidal blood flow." @default.
- W2026560639 created "2016-06-24" @default.
- W2026560639 creator A5005178539 @default.
- W2026560639 creator A5042209091 @default.
- W2026560639 creator A5076343259 @default.
- W2026560639 date "2004-07-01" @default.
- W2026560639 modified "2023-09-24" @default.
- W2026560639 title "Endothelin-1 distribution and basolateral secretion in the retinal pigment epithelium" @default.
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- W2026560639 doi "https://doi.org/10.1016/j.exer.2004.03.002" @default.
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