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• W2026562276 abstract "A central goal of vaccine research is to identify a vaccine-induced immune response that predicts protection from infection or disease. The term correlate of protection has been used to refer to at least 3 distinct concepts, which has resulted in confusion surrounding this topic. We propose precise definitions of these different concepts of immune correlates, using the nomenclature correlate of risk, level 1 surrogate of protection, and level 2 surrogate of protection. We suggest a general framework for assessing these 3 levels of immune correlates in vaccine efficacy trials. To demonstrate the proposed principles, we analyze data from a 1943 influenza vaccine field trial, supporting Weiss strain A—specific antibody titers as a level 1 surrogate of protection. Other real and simulated examples are also discussed." @default.
• W2026562276 created "2016-06-24" @default.
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• W2026562276 date "2007-11-01" @default.
• W2026562276 modified "2023-10-17" @default.
• W2026562276 title "A Framework for Assessing Immunological Correlates of Protection in Vaccine Trials" @default.
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• W2026562276 doi "https://doi.org/10.1086/522428" @default.
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