Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026573407> ?p ?o ?g. }
- W2026573407 endingPage "1475" @default.
- W2026573407 startingPage "1465" @default.
- W2026573407 abstract "Mineral and bone disorder (MBD) begins early in the course of chronic kidney disease (CKD). Phosphate imbalance in CKD-MBD can lead to various pathologies of clinical importance such as further deterioration of kidney function, cardiovascular complications, renal osteodystrophy and increased mortality.The authors conducted a systematic review of the biomedical literature to evaluate currently available drugs and new phosphate binder therapeutics in development.There is a need to continue searching for novel phosphate binders that better match an 'ideal' product profile. This profile should have: i) a product that is highly efficient in binding phosphate; ii) low patient compliance issues; iii) minimal interaction with other drugs; and iv) reduced side effects and safety concerns. Targeting alternative mechanisms, such as developing inhibitors for intestinal type II sodium-dependent phosphate co-transporter, may also improve the limitations of phosphate binder therapeutics. Current medical practice focuses on using serum phosphorus levels as the only marker for detecting, monitoring and treating phosphate imbalance in CKD. However, the consequences of phosphate imbalance are evident in non-dialysis patients before serum phosphate levels rise above the normal range. There is a need to search for other markers to guide detection and treatment of clinically significant alterations in phosphate metabolism of non-dialysis CKD." @default.
- W2026573407 created "2016-06-24" @default.
- W2026573407 creator A5014957818 @default.
- W2026573407 creator A5034166395 @default.
- W2026573407 date "2014-06-26" @default.
- W2026573407 modified "2023-09-23" @default.
- W2026573407 title "Is there a need for new phosphate binders to treat phosphate imbalance associated with chronic kidney disease?" @default.
- W2026573407 cites W1488644928 @default.
- W2026573407 cites W1543423153 @default.
- W2026573407 cites W1551618417 @default.
- W2026573407 cites W1964777557 @default.
- W2026573407 cites W1973733126 @default.
- W2026573407 cites W1979374558 @default.
- W2026573407 cites W1986900920 @default.
- W2026573407 cites W1992788375 @default.
- W2026573407 cites W1993528712 @default.
- W2026573407 cites W1993637240 @default.
- W2026573407 cites W1994661134 @default.
- W2026573407 cites W2003341788 @default.
- W2026573407 cites W2003511993 @default.
- W2026573407 cites W2004109986 @default.
- W2026573407 cites W2027479037 @default.
- W2026573407 cites W2031311109 @default.
- W2026573407 cites W2035221187 @default.
- W2026573407 cites W2043779931 @default.
- W2026573407 cites W2063218094 @default.
- W2026573407 cites W2069868276 @default.
- W2026573407 cites W2073545698 @default.
- W2026573407 cites W2077315258 @default.
- W2026573407 cites W2087295199 @default.
- W2026573407 cites W2097854176 @default.
- W2026573407 cites W2098795260 @default.
- W2026573407 cites W2102109777 @default.
- W2026573407 cites W2102420952 @default.
- W2026573407 cites W2102734552 @default.
- W2026573407 cites W2103174508 @default.
- W2026573407 cites W2103257944 @default.
- W2026573407 cites W2103572684 @default.
- W2026573407 cites W2107207648 @default.
- W2026573407 cites W2107420262 @default.
- W2026573407 cites W2116678861 @default.
- W2026573407 cites W2117116215 @default.
- W2026573407 cites W2118308161 @default.
- W2026573407 cites W2119878754 @default.
- W2026573407 cites W2120008276 @default.
- W2026573407 cites W2121615286 @default.
- W2026573407 cites W2122295878 @default.
- W2026573407 cites W2126255420 @default.
- W2026573407 cites W2131843552 @default.
- W2026573407 cites W2132226077 @default.
- W2026573407 cites W2132700529 @default.
- W2026573407 cites W2133808321 @default.
- W2026573407 cites W2135786480 @default.
- W2026573407 cites W2138484848 @default.
- W2026573407 cites W2141385164 @default.
- W2026573407 cites W2142694141 @default.
- W2026573407 cites W2145582432 @default.
- W2026573407 cites W2145632027 @default.
- W2026573407 cites W2152171089 @default.
- W2026573407 cites W2152182062 @default.
- W2026573407 cites W2155127013 @default.
- W2026573407 cites W2160919161 @default.
- W2026573407 cites W2161630557 @default.
- W2026573407 cites W2163181937 @default.
- W2026573407 cites W2168524187 @default.
- W2026573407 cites W2615305188 @default.
- W2026573407 cites W7881856 @default.
- W2026573407 cites W2156526966 @default.
- W2026573407 doi "https://doi.org/10.1517/13543784.2014.933808" @default.
- W2026573407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24965615" @default.
- W2026573407 hasPublicationYear "2014" @default.
- W2026573407 type Work @default.
- W2026573407 sameAs 2026573407 @default.
- W2026573407 citedByCount "5" @default.
- W2026573407 countsByYear W20265734072015 @default.
- W2026573407 countsByYear W20265734072016 @default.
- W2026573407 countsByYear W20265734072018 @default.
- W2026573407 countsByYear W20265734072020 @default.
- W2026573407 crossrefType "journal-article" @default.
- W2026573407 hasAuthorship W2026573407A5014957818 @default.
- W2026573407 hasAuthorship W2026573407A5034166395 @default.
- W2026573407 hasConcept C126322002 @default.
- W2026573407 hasConcept C134018914 @default.
- W2026573407 hasConcept C159641895 @default.
- W2026573407 hasConcept C177713679 @default.
- W2026573407 hasConcept C185592680 @default.
- W2026573407 hasConcept C2776036575 @default.
- W2026573407 hasConcept C2776699218 @default.
- W2026573407 hasConcept C2777132085 @default.
- W2026573407 hasConcept C2778653478 @default.
- W2026573407 hasConcept C2779148903 @default.
- W2026573407 hasConcept C2779978075 @default.
- W2026573407 hasConcept C55493867 @default.
- W2026573407 hasConcept C71924100 @default.
- W2026573407 hasConcept C98274493 @default.
- W2026573407 hasConceptScore W2026573407C126322002 @default.
- W2026573407 hasConceptScore W2026573407C134018914 @default.
- W2026573407 hasConceptScore W2026573407C159641895 @default.