Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026574531> ?p ?o ?g. }
- W2026574531 endingPage "357" @default.
- W2026574531 startingPage "347" @default.
- W2026574531 abstract "The transcription elongation factor TFIIS induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II. We have diffused TFIIS into Pol II crystals and derived a model of the Pol II-TFIIS complex from X-ray diffraction data to 3.8 Å resolution. TFIIS extends from the polymerase surface via a pore to the internal active site, spanning a distance of 100 Å. Two essential and invariant acidic residues in a TFIIS loop complement the Pol II active site and could position a metal ion and a water molecule for hydrolytic RNA cleavage. TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active center. Our results support the idea that Pol II contains a single tunable active site for RNA polymerization and cleavage, in contrast to DNA polymerases with two separate active sites for DNA polymerization and cleavage." @default.
- W2026574531 created "2016-06-24" @default.
- W2026574531 creator A5008281609 @default.
- W2026574531 creator A5040506845 @default.
- W2026574531 creator A5081144021 @default.
- W2026574531 date "2003-08-01" @default.
- W2026574531 modified "2023-10-14" @default.
- W2026574531 title "Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage" @default.
- W2026574531 cites W1485158076 @default.
- W2026574531 cites W1485624324 @default.
- W2026574531 cites W1518023895 @default.
- W2026574531 cites W1519899019 @default.
- W2026574531 cites W1563789995 @default.
- W2026574531 cites W1967615956 @default.
- W2026574531 cites W1970131126 @default.
- W2026574531 cites W1973862916 @default.
- W2026574531 cites W1975941280 @default.
- W2026574531 cites W1979645700 @default.
- W2026574531 cites W1980888037 @default.
- W2026574531 cites W1987780031 @default.
- W2026574531 cites W1987911801 @default.
- W2026574531 cites W1992864103 @default.
- W2026574531 cites W1994801641 @default.
- W2026574531 cites W1995017064 @default.
- W2026574531 cites W1996910069 @default.
- W2026574531 cites W2004617021 @default.
- W2026574531 cites W2004971378 @default.
- W2026574531 cites W2005744558 @default.
- W2026574531 cites W2006373999 @default.
- W2026574531 cites W2010145498 @default.
- W2026574531 cites W2013083986 @default.
- W2026574531 cites W2018002092 @default.
- W2026574531 cites W2020957704 @default.
- W2026574531 cites W2034000906 @default.
- W2026574531 cites W2035597391 @default.
- W2026574531 cites W2038724843 @default.
- W2026574531 cites W2044690677 @default.
- W2026574531 cites W2052377115 @default.
- W2026574531 cites W2054556609 @default.
- W2026574531 cites W2054915693 @default.
- W2026574531 cites W2059691911 @default.
- W2026574531 cites W2062630554 @default.
- W2026574531 cites W2064779963 @default.
- W2026574531 cites W2065234950 @default.
- W2026574531 cites W2067953727 @default.
- W2026574531 cites W2072459861 @default.
- W2026574531 cites W2074206760 @default.
- W2026574531 cites W2076946689 @default.
- W2026574531 cites W2077160219 @default.
- W2026574531 cites W2078784388 @default.
- W2026574531 cites W2080476827 @default.
- W2026574531 cites W2081524593 @default.
- W2026574531 cites W2084622414 @default.
- W2026574531 cites W2092558918 @default.
- W2026574531 cites W2093608893 @default.
- W2026574531 cites W2094184203 @default.
- W2026574531 cites W2096275987 @default.
- W2026574531 cites W2100132835 @default.
- W2026574531 cites W2103995020 @default.
- W2026574531 cites W2110473043 @default.
- W2026574531 cites W2110840208 @default.
- W2026574531 cites W2120920712 @default.
- W2026574531 cites W2134814213 @default.
- W2026574531 cites W2153023603 @default.
- W2026574531 cites W2158364267 @default.
- W2026574531 cites W2163043365 @default.
- W2026574531 cites W2170565831 @default.
- W2026574531 cites W2171526912 @default.
- W2026574531 cites W2801944549 @default.
- W2026574531 cites W4229676100 @default.
- W2026574531 cites W4239023878 @default.
- W2026574531 doi "https://doi.org/10.1016/s0092-8674(03)00598-1" @default.
- W2026574531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12914699" @default.
- W2026574531 hasPublicationYear "2003" @default.
- W2026574531 type Work @default.
- W2026574531 sameAs 2026574531 @default.
- W2026574531 citedByCount "310" @default.
- W2026574531 countsByYear W20265745312012 @default.
- W2026574531 countsByYear W20265745312013 @default.
- W2026574531 countsByYear W20265745312014 @default.
- W2026574531 countsByYear W20265745312015 @default.
- W2026574531 countsByYear W20265745312016 @default.
- W2026574531 countsByYear W20265745312017 @default.
- W2026574531 countsByYear W20265745312018 @default.
- W2026574531 countsByYear W20265745312019 @default.
- W2026574531 countsByYear W20265745312020 @default.
- W2026574531 countsByYear W20265745312021 @default.
- W2026574531 countsByYear W20265745312022 @default.
- W2026574531 countsByYear W20265745312023 @default.
- W2026574531 crossrefType "journal-article" @default.
- W2026574531 hasAuthorship W2026574531A5008281609 @default.
- W2026574531 hasAuthorship W2026574531A5040506845 @default.
- W2026574531 hasAuthorship W2026574531A5081144021 @default.
- W2026574531 hasBestOaLocation W20265745311 @default.
- W2026574531 hasConcept C101762097 @default.
- W2026574531 hasConcept C104317684 @default.
- W2026574531 hasConcept C131140672 @default.
- W2026574531 hasConcept C138885662 @default.