FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026576068> ?p ?o ?g. }

• W2026576068 endingPage "98" @default.
• W2026576068 startingPage "92" @default.
• W2026576068 abstract "The present study was carried out to characterize ACE inhibitory peptides which are released from the trypsin hydrolysate of wheat gluten protein. In silico proteolitic digestion of a high molecular weight glutenin subunit was performed. Among the resultant fragments, four peptides were selected for chemical synthesis based on the chemoinformatics studies and docking properties. The ACE inhibitory activity and kinetic parameters of the most important peptides were determined. Molecular docking simulation was also performed to predict the sites on ACE in which these peptides bind and displayed inhibition mechanisms. Two peptide sequences of IPALLKR (P4) and AQQLAAQLPAMCR (P6) showed higher ACE inhibitory activity among peptide collection. The IC50 values of P6 and P4 were 43 ± 1.3 μM and 68 ± 2.8 μM, respectively. P6 peptide was proved to be a more potent ACE inhibitor than P4 peptide. Lineweaver-Burk plots revealed that P6 and P4 behaved as non-competitive and competitive ACE inhibitors, respectively. The simulations showed that P4 bound to the active site region. Conversely, P6 bound to the N-terminus entrance of substrate tunnel and obstructed the substrate access into the catalytic site. Overall, the results showed that these peptides would be considered as a model for discovering new bio-compatible ACE inhibitors." @default.
• W2026576068 created "2016-06-24" @default.
• W2026576068 creator A5001219162 @default.
• W2026576068 creator A5017920418 @default.
• W2026576068 creator A5031580263 @default.
• W2026576068 creator A5055020590 @default.
• W2026576068 creator A5063432783 @default.
• W2026576068 creator A5078617437 @default.
• W2026576068 date "2014-07-01" @default.
• W2026576068 modified "2023-10-16" @default.
• W2026576068 title "Potential angiotensin I converting enzyme inhibitory peptides from gluten hydrolysate: Biochemical characterization and molecular docking study" @default.
• W2026576068 cites W1515235085 @default.
• W2026576068 cites W1544898357 @default.
• W2026576068 cites W1590215134 @default.
• W2026576068 cites W1971170015 @default.
• W2026576068 cites W1972091682 @default.
• W2026576068 cites W1997379621 @default.
• W2026576068 cites W2000220201 @default.
• W2026576068 cites W2000391618 @default.
• W2026576068 cites W2010937249 @default.
• W2026576068 cites W2033342433 @default.
• W2026576068 cites W2037671879 @default.
• W2026576068 cites W2046804342 @default.
• W2026576068 cites W2050000500 @default.
• W2026576068 cites W2052418725 @default.
• W2026576068 cites W2052439357 @default.
• W2026576068 cites W2054952495 @default.
• W2026576068 cites W2062282696 @default.
• W2026576068 cites W2063694823 @default.
• W2026576068 cites W2067060165 @default.
• W2026576068 cites W2093645202 @default.
• W2026576068 cites W2097550278 @default.
• W2026576068 cites W2099476122 @default.
• W2026576068 cites W21242487 @default.
• W2026576068 cites W2137052779 @default.
• W2026576068 cites W2151065787 @default.
• W2026576068 cites W2154609728 @default.
• W2026576068 cites W2164090811 @default.
• W2026576068 cites W2205908610 @default.
• W2026576068 cites W2339695553 @default.
• W2026576068 cites W4253959951 @default.
• W2026576068 doi "https://doi.org/10.1016/j.jcs.2014.01.019" @default.
• W2026576068 hasPublicationYear "2014" @default.
• W2026576068 type Work @default.
• W2026576068 sameAs 2026576068 @default.
• W2026576068 citedByCount "27" @default.
• W2026576068 countsByYear W20265760682014 @default.
• W2026576068 countsByYear W20265760682015 @default.
• W2026576068 countsByYear W20265760682016 @default.
• W2026576068 countsByYear W20265760682017 @default.
• W2026576068 countsByYear W20265760682018 @default.
• W2026576068 countsByYear W20265760682019 @default.
• W2026576068 countsByYear W20265760682020 @default.
• W2026576068 countsByYear W20265760682021 @default.
• W2026576068 countsByYear W20265760682022 @default.
• W2026576068 countsByYear W20265760682023 @default.
• W2026576068 crossrefType "journal-article" @default.
• W2026576068 hasAuthorship W2026576068A5001219162 @default.
• W2026576068 hasAuthorship W2026576068A5017920418 @default.
• W2026576068 hasAuthorship W2026576068A5031580263 @default.
• W2026576068 hasAuthorship W2026576068A5055020590 @default.
• W2026576068 hasAuthorship W2026576068A5063432783 @default.
• W2026576068 hasAuthorship W2026576068A5078617437 @default.
• W2026576068 hasConcept C104292427 @default.
• W2026576068 hasConcept C104317684 @default.
• W2026576068 hasConcept C159110408 @default.
• W2026576068 hasConcept C181199279 @default.
• W2026576068 hasConcept C185592680 @default.
• W2026576068 hasConcept C202751555 @default.
• W2026576068 hasConcept C2775905019 @default.
• W2026576068 hasConcept C2777752497 @default.
• W2026576068 hasConcept C2779281246 @default.
• W2026576068 hasConcept C2779687958 @default.
• W2026576068 hasConcept C2780340462 @default.
• W2026576068 hasConcept C28800991 @default.
• W2026576068 hasConcept C41183919 @default.
• W2026576068 hasConcept C41685203 @default.
• W2026576068 hasConcept C55493867 @default.
• W2026576068 hasConcept C71924100 @default.
• W2026576068 hasConcept C94412978 @default.
• W2026576068 hasConceptScore W2026576068C104292427 @default.
• W2026576068 hasConceptScore W2026576068C104317684 @default.
• W2026576068 hasConceptScore W2026576068C159110408 @default.
• W2026576068 hasConceptScore W2026576068C181199279 @default.
• W2026576068 hasConceptScore W2026576068C185592680 @default.
• W2026576068 hasConceptScore W2026576068C202751555 @default.
• W2026576068 hasConceptScore W2026576068C2775905019 @default.
• W2026576068 hasConceptScore W2026576068C2777752497 @default.
• W2026576068 hasConceptScore W2026576068C2779281246 @default.
• W2026576068 hasConceptScore W2026576068C2779687958 @default.
• W2026576068 hasConceptScore W2026576068C2780340462 @default.
• W2026576068 hasConceptScore W2026576068C28800991 @default.
• W2026576068 hasConceptScore W2026576068C41183919 @default.
• W2026576068 hasConceptScore W2026576068C41685203 @default.
• W2026576068 hasConceptScore W2026576068C55493867 @default.
• W2026576068 hasConceptScore W2026576068C71924100 @default.
• W2026576068 hasConceptScore W2026576068C94412978 @default.
• W2026576068 hasIssue "1" @default.

• next