Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026578436> ?p ?o ?g. }
- W2026578436 endingPage "146" @default.
- W2026578436 startingPage "131" @default.
- W2026578436 abstract "The nucleus accumbens (NAc) has emerged as an important part of the neural circuitry regulating depressive-like behaviors. Given that the NAc GABAergic medium spiny neurons project to the ventral pallidum (VP), it is reasonable to suggest that the VP may also be involved in these behaviors. Consequently, we explored the role of the VP GABAergic terminals during depressive-like behaviors in rats using the forced swim test (FST) and the sucrose preference test (SPT). Microdialysis coupled with micellar electrokinetic chromatography was used to monitor in vivo changes of GABA in the VP during the FST. GABA levels significantly increased during day-1 and day-2 during swimming, returning to the pre-swimming levels after the test. Basal concentrations of GABA on day-2 of the FST significantly increased with respect to day-1. In another set of experiments, intra-VP injections of vigabatrin (a GABA transaminase inhibitor) increased extracellular GABA and immobility behaviors in the FST while the direct GABAA receptor antagonist bicuculline reduced immobility behaviors. In the SPT, intra-VP vigabatrin injection significantly reduced preference for sucrose while bicuculline did not produce any change. At the postsynaptic side, we used semiquantitative RT-PCR to measure mRNA expression of 17 GABAA receptor subunits (α1–α6, β1–β3, γ2, δ, ε, θ, π, and ρ1–ρ3) in rats subjected to the FST. We found a significant reduction of α3 and γ2 subunit expression and an increase of δ subunit expression after day-2 in rats subject to the FST which might enhance tonic inhibition of the VP. Furthermore, immunoblot experiments revealed that protein expression of γ2 and δ subunits changed 6 days after FST in a way similar to mRNA expression. These results suggest that the enhanced VP-GABAergic tone might trigger a low motivational state, anhedonia and a possible memory mechanism for unpleasant experiences." @default.
- W2026578436 created "2016-06-24" @default.
- W2026578436 creator A5013570314 @default.
- W2026578436 creator A5018657020 @default.
- W2026578436 creator A5019004086 @default.
- W2026578436 creator A5019454541 @default.
- W2026578436 creator A5031932651 @default.
- W2026578436 creator A5042061526 @default.
- W2026578436 creator A5047697348 @default.
- W2026578436 creator A5078610528 @default.
- W2026578436 creator A5084923375 @default.
- W2026578436 date "2011-11-01" @default.
- W2026578436 modified "2023-10-17" @default.
- W2026578436 title "Enhanced GABAergic tone in the ventral pallidum: memory of unpleasant experiences?" @default.
- W2026578436 cites W1524203275 @default.
- W2026578436 cites W1563037009 @default.
- W2026578436 cites W1576251718 @default.
- W2026578436 cites W1576725517 @default.
- W2026578436 cites W1607092694 @default.
- W2026578436 cites W1808986223 @default.
- W2026578436 cites W1828744404 @default.
- W2026578436 cites W1928329059 @default.
- W2026578436 cites W1935461641 @default.
- W2026578436 cites W1962727914 @default.
- W2026578436 cites W1966725378 @default.
- W2026578436 cites W1967380120 @default.
- W2026578436 cites W1972212598 @default.
- W2026578436 cites W1972449722 @default.
- W2026578436 cites W1974440180 @default.
- W2026578436 cites W1986371668 @default.
- W2026578436 cites W1988240593 @default.
- W2026578436 cites W1989359395 @default.
- W2026578436 cites W1991101987 @default.
- W2026578436 cites W1996883125 @default.
- W2026578436 cites W1997976229 @default.
- W2026578436 cites W1998229125 @default.
- W2026578436 cites W1998839035 @default.
- W2026578436 cites W2002448151 @default.
- W2026578436 cites W2002498391 @default.
- W2026578436 cites W2003973769 @default.
- W2026578436 cites W2006882116 @default.
- W2026578436 cites W2007816528 @default.
- W2026578436 cites W2008397144 @default.
- W2026578436 cites W2009249193 @default.
- W2026578436 cites W2015236121 @default.
- W2026578436 cites W2016321438 @default.
- W2026578436 cites W2016648535 @default.
- W2026578436 cites W2017187845 @default.
- W2026578436 cites W2017253704 @default.
- W2026578436 cites W2019043248 @default.
- W2026578436 cites W2021194790 @default.
- W2026578436 cites W2021927267 @default.
- W2026578436 cites W2022488498 @default.
- W2026578436 cites W2024167856 @default.
- W2026578436 cites W2027379325 @default.
- W2026578436 cites W2029973582 @default.
- W2026578436 cites W2032841846 @default.
- W2026578436 cites W2033168042 @default.
- W2026578436 cites W2034531255 @default.
- W2026578436 cites W2035352436 @default.
- W2026578436 cites W2035486944 @default.
- W2026578436 cites W2035590629 @default.
- W2026578436 cites W2036939803 @default.
- W2026578436 cites W2037161788 @default.
- W2026578436 cites W2037558876 @default.
- W2026578436 cites W2042111626 @default.
- W2026578436 cites W2044275480 @default.
- W2026578436 cites W2044418826 @default.
- W2026578436 cites W2045766529 @default.
- W2026578436 cites W2046274203 @default.
- W2026578436 cites W2047243202 @default.
- W2026578436 cites W2050179227 @default.
- W2026578436 cites W2050243692 @default.
- W2026578436 cites W2051819610 @default.
- W2026578436 cites W2052409790 @default.
- W2026578436 cites W2053544091 @default.
- W2026578436 cites W2053929600 @default.
- W2026578436 cites W2058572791 @default.
- W2026578436 cites W2062186332 @default.
- W2026578436 cites W2062259372 @default.
- W2026578436 cites W2064952442 @default.
- W2026578436 cites W2071313506 @default.
- W2026578436 cites W2071441737 @default.
- W2026578436 cites W2072023349 @default.
- W2026578436 cites W2072627631 @default.
- W2026578436 cites W2073838182 @default.
- W2026578436 cites W2074217816 @default.
- W2026578436 cites W2074461560 @default.
- W2026578436 cites W2076831157 @default.
- W2026578436 cites W2077303895 @default.
- W2026578436 cites W2077491181 @default.
- W2026578436 cites W2080634958 @default.
- W2026578436 cites W2082730382 @default.
- W2026578436 cites W2084654819 @default.
- W2026578436 cites W2085467925 @default.
- W2026578436 cites W2085633489 @default.
- W2026578436 cites W2086013591 @default.
- W2026578436 cites W2088143216 @default.