FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026583691> ?p ?o ?g. }

• W2026583691 endingPage "481" @default.
• W2026583691 startingPage "475" @default.
• W2026583691 abstract "Fetal hepatocyte cultures were used to investigate tyrosine aminotransferase (TyrAT) expression during development. Previous studies showed that TyrAT is synthesized by hepatocytes isolated from 15-day-gestation fetuses maintained in culture for two or more days, then exposed to dexamethasone. TyrAT expression was essentially undetectable on the first day of culture of hepatocytes derived from 15-day-gestation, or less mature, fetuses. Dexamethasone and cAMP are potent inducers of TyrAT and they synergistically induce TyrAT to extremely high levels when added simultaneously to cultured fetal hepatocytes. The effects of dibutyryl-cAMP (Bt2cAMP) alone and in combination with dexamethasone on TyrAT expression are investigated. Hepatocytes isolated from 15-day-gestation fetuses exposed to both inducers possessed detectable levels of TyrAT activity and mRNA on day 1 of culture, and this increased by day 3. In contrast, hepatocytes exposed to either inducing agent alone were essentially negative on day 1, but positive on day 3. This was shown to be a consequence of transcription. When 13-day-gestation hepatocytes were maintained in culture under identical conditions detectable levels of TyrAT mRNA were evident on day 1, and this increased by day 3. Immunocytochemical studies revealed that the appearance and subsequent increase in TyrAT production elicited by dexamethasone and Bt2cAMP were due to changes in the proportion of hepatocytes expressing the enzyme. Therefore, in the presence of both dexamethasone and Bt2cAMP, TyrAT expression can be detected in some cells at an earlier stage of liver development than reported previously." @default.
• W2026583691 created "2016-06-24" @default.
• W2026583691 creator A5026215456 @default.
• W2026583691 creator A5086442908 @default.
• W2026583691 date "1991-07-01" @default.
• W2026583691 modified "2023-10-18" @default.
• W2026583691 title "Effects of dexamethasone and cAMP on tyrosine aminotransferase expression in cultured fetal rat hepatocytes" @default.
• W2026583691 cites W141047193 @default.
• W2026583691 cites W1500057643 @default.
• W2026583691 cites W1558363775 @default.
• W2026583691 cites W1571266414 @default.
• W2026583691 cites W179214917 @default.
• W2026583691 cites W1879192670 @default.
• W2026583691 cites W1913034229 @default.
• W2026583691 cites W1964365846 @default.
• W2026583691 cites W1966794733 @default.
• W2026583691 cites W1972336344 @default.
• W2026583691 cites W1981048571 @default.
• W2026583691 cites W1982905517 @default.
• W2026583691 cites W2003762965 @default.
• W2026583691 cites W2007172363 @default.
• W2026583691 cites W2010561229 @default.
• W2026583691 cites W2024628809 @default.
• W2026583691 cites W2031687390 @default.
• W2026583691 cites W2032848829 @default.
• W2026583691 cites W2033302775 @default.
• W2026583691 cites W2050951221 @default.
• W2026583691 cites W2051819610 @default.
• W2026583691 cites W2052059711 @default.
• W2026583691 cites W2052105069 @default.
• W2026583691 cites W2053780238 @default.
• W2026583691 cites W206773894 @default.
• W2026583691 cites W2070083696 @default.
• W2026583691 cites W2075440500 @default.
• W2026583691 cites W2079794998 @default.
• W2026583691 cites W2080525072 @default.
• W2026583691 cites W2162050937 @default.
• W2026583691 cites W2165590430 @default.
• W2026583691 cites W2335703178 @default.
• W2026583691 cites W2394627674 @default.
• W2026583691 cites W2394998609 @default.
• W2026583691 cites W2896663432 @default.
• W2026583691 cites W4213027533 @default.
• W2026583691 cites W4229921061 @default.
• W2026583691 cites W97321680 @default.
• W2026583691 doi "https://doi.org/10.1111/j.1432-1033.1991.tb16146.x" @default.
• W2026583691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1676968" @default.
• W2026583691 hasPublicationYear "1991" @default.
• W2026583691 type Work @default.
• W2026583691 sameAs 2026583691 @default.
• W2026583691 citedByCount "15" @default.
• W2026583691 countsByYear W20265836912019 @default.
• W2026583691 countsByYear W20265836912020 @default.
• W2026583691 crossrefType "journal-article" @default.
• W2026583691 hasAuthorship W2026583691A5026215456 @default.
• W2026583691 hasAuthorship W2026583691A5086442908 @default.
• W2026583691 hasBestOaLocation W20265836911 @default.
• W2026583691 hasConcept C104317684 @default.
• W2026583691 hasConcept C126322002 @default.
• W2026583691 hasConcept C132154277 @default.
• W2026583691 hasConcept C134018914 @default.
• W2026583691 hasConcept C16685009 @default.
• W2026583691 hasConcept C172680121 @default.
• W2026583691 hasConcept C181199279 @default.
• W2026583691 hasConcept C202751555 @default.
• W2026583691 hasConcept C2225953 @default.
• W2026583691 hasConcept C2776200302 @default.
• W2026583691 hasConcept C2776491826 @default.
• W2026583691 hasConcept C2779234561 @default.
• W2026583691 hasConcept C2780401358 @default.
• W2026583691 hasConcept C46973012 @default.
• W2026583691 hasConcept C54355233 @default.
• W2026583691 hasConcept C55493867 @default.
• W2026583691 hasConcept C71924100 @default.
• W2026583691 hasConcept C81885089 @default.
• W2026583691 hasConcept C86803240 @default.
• W2026583691 hasConceptScore W2026583691C104317684 @default.
• W2026583691 hasConceptScore W2026583691C126322002 @default.
• W2026583691 hasConceptScore W2026583691C132154277 @default.
• W2026583691 hasConceptScore W2026583691C134018914 @default.
• W2026583691 hasConceptScore W2026583691C16685009 @default.
• W2026583691 hasConceptScore W2026583691C172680121 @default.
• W2026583691 hasConceptScore W2026583691C181199279 @default.
• W2026583691 hasConceptScore W2026583691C202751555 @default.
• W2026583691 hasConceptScore W2026583691C2225953 @default.
• W2026583691 hasConceptScore W2026583691C2776200302 @default.
• W2026583691 hasConceptScore W2026583691C2776491826 @default.
• W2026583691 hasConceptScore W2026583691C2779234561 @default.
• W2026583691 hasConceptScore W2026583691C2780401358 @default.
• W2026583691 hasConceptScore W2026583691C46973012 @default.
• W2026583691 hasConceptScore W2026583691C54355233 @default.
• W2026583691 hasConceptScore W2026583691C55493867 @default.
• W2026583691 hasConceptScore W2026583691C71924100 @default.
• W2026583691 hasConceptScore W2026583691C81885089 @default.
• W2026583691 hasConceptScore W2026583691C86803240 @default.
• W2026583691 hasIssue "2" @default.
• W2026583691 hasLocation W20265836911 @default.
• W2026583691 hasLocation W20265836912 @default.

• next