FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026597449> ?p ?o ?g. }

• W2026597449 endingPage "1598" @default.
• W2026597449 startingPage "1588" @default.
• W2026597449 abstract "Normal endocrine development and function require nuclear hormone receptor SF-1 (steroidogenic factor 1). To understand the molecular mechanism of SF-1 action, we have investigated its domain function by mutagenesis and functional analyses. Our mutant studies show that the putative AF2 (activation function 2) helix located at the C-terminal end is indispensable for gene activation. SF-1 does not have an N-terminal AF1 domain. Instead, it contains a unique FP region, composed of the Ftz-F1 box and the proline cluster, after the zinc finger motif. The FP region interacts with transcription factor IIB (TFIIB) in vitro. This interaction requires residues 178–201 of TFIIB, a domain capable of binding several transcription factors. The FP region also mediates physical interaction with c-Jun, and this interaction greatly enhances SF-1 activity. The putative SF-1 ligand, 25-hydroxycholesterol, has no effects on these bindings. In addition, the Ftz-F1 box contains a bipartite nuclear localization signal (NLS). Removing the basic residues at either end of the key nuclear localization sequence NLS2.2 abolishes the nuclear transport. Expression of mutants containing only the FP region or lacking the AF2 domain blocks wild-type SF-1 activity in cells. By contrast, the mutant having a truncated nuclear localization signal lacks this dominant negative effect. These results delineate the importance of the FP and AF2 regions in nuclear localization, protein-protein interaction, and transcriptional activation." @default.
• W2026597449 created "2016-06-24" @default.
• W2026597449 creator A5004820180 @default.
• W2026597449 creator A5038587440 @default.
• W2026597449 creator A5071977277 @default.
• W2026597449 creator A5075798542 @default.
• W2026597449 creator A5083530015 @default.
• W2026597449 creator A5089594709 @default.
• W2026597449 date "1999-09-01" @default.
• W2026597449 modified "2023-10-05" @default.
• W2026597449 title "Function of Steroidogenic Factor 1 Domains in Nuclear Localization, Transactivation, and Interaction with Transcription Factor TFIIB and c-Jun" @default.
• W2026597449 cites W1213045642 @default.
• W2026597449 cites W1482432683 @default.
• W2026597449 cites W1495912963 @default.
• W2026597449 cites W1590197184 @default.
• W2026597449 cites W1640150978 @default.
• W2026597449 cites W1646199134 @default.
• W2026597449 cites W1723187988 @default.
• W2026597449 cites W1798563091 @default.
• W2026597449 cites W1973253404 @default.
• W2026597449 cites W1974313971 @default.
• W2026597449 cites W1977873240 @default.
• W2026597449 cites W1978796672 @default.
• W2026597449 cites W1987783037 @default.
• W2026597449 cites W1996124735 @default.
• W2026597449 cites W1997359962 @default.
• W2026597449 cites W2003002984 @default.
• W2026597449 cites W2005608222 @default.
• W2026597449 cites W2008822380 @default.
• W2026597449 cites W2009149917 @default.
• W2026597449 cites W2009443375 @default.
• W2026597449 cites W2010026543 @default.
• W2026597449 cites W2010416554 @default.
• W2026597449 cites W2011189608 @default.
• W2026597449 cites W2012324003 @default.
• W2026597449 cites W2022040863 @default.
• W2026597449 cites W2036684049 @default.
• W2026597449 cites W2037404178 @default.
• W2026597449 cites W2039887170 @default.
• W2026597449 cites W2039997181 @default.
• W2026597449 cites W2040687221 @default.
• W2026597449 cites W2040808575 @default.
• W2026597449 cites W2047350170 @default.
• W2026597449 cites W2051520501 @default.
• W2026597449 cites W2054736204 @default.
• W2026597449 cites W2055540960 @default.
• W2026597449 cites W2055723072 @default.
• W2026597449 cites W2072386144 @default.
• W2026597449 cites W2086725260 @default.
• W2026597449 cites W2089020033 @default.
• W2026597449 cites W2090195590 @default.
• W2026597449 cites W2094375093 @default.
• W2026597449 cites W2095362827 @default.
• W2026597449 cites W2098035462 @default.
• W2026597449 cites W2098464529 @default.
• W2026597449 cites W2100859941 @default.
• W2026597449 cites W2112966757 @default.
• W2026597449 cites W2117464070 @default.
• W2026597449 cites W2118516988 @default.
• W2026597449 cites W2133873481 @default.
• W2026597449 cites W2138910677 @default.
• W2026597449 cites W2139723733 @default.
• W2026597449 cites W2144206181 @default.
• W2026597449 cites W2148636696 @default.
• W2026597449 cites W2156744272 @default.
• W2026597449 cites W2163173672 @default.
• W2026597449 cites W2177151394 @default.
• W2026597449 cites W270887500 @default.
• W2026597449 doi "https://doi.org/10.1210/mend.13.9.0349" @default.
• W2026597449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10478848" @default.
• W2026597449 hasPublicationYear "1999" @default.
• W2026597449 type Work @default.
• W2026597449 sameAs 2026597449 @default.
• W2026597449 citedByCount "68" @default.
• W2026597449 countsByYear W20265974492012 @default.
• W2026597449 countsByYear W20265974492013 @default.
• W2026597449 countsByYear W20265974492014 @default.
• W2026597449 countsByYear W20265974492015 @default.
• W2026597449 countsByYear W20265974492017 @default.
• W2026597449 countsByYear W20265974492018 @default.
• W2026597449 countsByYear W20265974492019 @default.
• W2026597449 countsByYear W20265974492020 @default.
• W2026597449 countsByYear W20265974492023 @default.
• W2026597449 crossrefType "journal-article" @default.
• W2026597449 hasAuthorship W2026597449A5004820180 @default.
• W2026597449 hasAuthorship W2026597449A5038587440 @default.
• W2026597449 hasAuthorship W2026597449A5071977277 @default.
• W2026597449 hasAuthorship W2026597449A5075798542 @default.
• W2026597449 hasAuthorship W2026597449A5083530015 @default.
• W2026597449 hasAuthorship W2026597449A5089594709 @default.
• W2026597449 hasBestOaLocation W20265974491 @default.
• W2026597449 hasConcept C101762097 @default.
• W2026597449 hasConcept C104317684 @default.
• W2026597449 hasConcept C105208137 @default.
• W2026597449 hasConcept C1292079 @default.
• W2026597449 hasConcept C150194340 @default.
• W2026597449 hasConcept C153911025 @default.
• W2026597449 hasConcept C190062978 @default.

• next