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• W2026626439 abstract "RAS oncogenes play a critical role in oncogenic transformation and metastases formation. Here we show that Ha-ras greatly stimulates spontaneous metastatic activity of transformed cells through the Ras/RalGDS/RalA intracellular signaling pathway. Introduction of RalA alone leads to a drastic increase of metastatic activity of transformed cells. We demonstrate that metastatic ability of cells could be dramatically enhanced by RalA stimulation or, conversely, hampered by RalA suppression. Furthermore, we found that during in vivo selection cells acquire high metastatic properties as a result of endogenous RalA activation. The ability of RalA to induce metastasis was demonstrated in spontaneously transformed as well as in virus transformed fibroblasts." @default.
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• W2026626439 date "2004-09-27" @default.
• W2026626439 modified "2023-10-14" @default.
• W2026626439 title "The small G-protein RalA stimulates metastasis of transformed cells" @default.
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• W2026626439 doi "https://doi.org/10.1038/sj.onc.1208094" @default.
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