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- W2026637060 abstract "<h2>Abstract</h2><h3>Background</h3> During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation, normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis. <h3>Methods</h3> Rats were randomly assigned to 3 groups. group 1=control, group 2=experimental colitis, and group 3=colitis plus Met-RANTES treatment. On day 7 after colitis was induced, plasma tumor necrosis factor-α colon tissue myeloperoxidase and portal blood endotoxin levels were measured. Lymph node, liver, and spleen culture quantified bacterial translocation. <h3>Results</h3> Met-RANTES treatment resulted in significant decreases in colonic damage as well as bacterial translocation in experimental colitis. <h3>Conclusions</h3> These results suggest that chemokine receptor antagonists may potentially be useful in the treatment of IBDs." @default.
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- W2026637060 date "2006-01-01" @default.
- W2026637060 modified "2023-10-18" @default.
- W2026637060 title "Treatment with Met-RANTES decreases bacterial translocation in experimental colitis" @default.
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- W2026637060 doi "https://doi.org/10.1016/j.amjsurg.2005.10.005" @default.
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