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- W2026645310 abstract "Under modern vigorous ALL-treatment, prolonged survival of over 10 years (y) despite relapse can be observed occasionally: R.E. (f): Diagnosis Sept. 62 (age 12 ¼ y), first relapse 1 y later, 8 successive relapses within the next 9 y. CNS-leukemia developed after 11 ¾ y. She could be maintained in satisfactory condition during the final relapse lasting 4 y (1), but finally died from leukemia after 14 y of disease. A.T.(m) had insufficient treatment for his ALL from diagnosis in June 64 (age 14) to Dec. 64, when he relapsed. Under better treatment he remained in complete remission (CR) for 10½ y (off treatment for 5½ y). Relapse July 75, morphology and cytochemistry suggestive for AML. He died within 2½ months, 11 ¾ y after diagnosis. U.S. (m): Diagnosis in Feb. 67 (at 2 ¼ y). Bone marrow CR for 10 ¼ y until Hay 77 despite a first episode of CNS-leukemia in Aug. 69 already, and repeated CNS disease since 1971. At present (June 77) he is again in CR. K.M.(m): Diagnosis March 67 (age 2 ¼ y). After 1 year in CR seizures suggested CNS-leukemia, but CSF was normal. In March 69 (after 2 y) his bone marrow showed 17% blasts, but after an intensive DNM-course (with severe side effects) he remained in CR (8 ¼ + y, total disease duration 10 ¼ y). He is off treatment since 3½ y. - These cases show that prolonged survival is rarely compatible with frequent relapses. However, bhe final outlook for these children with rare exceptions remains bad." @default.
- W2026645310 created "2016-06-24" @default.
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- W2026645310 date "1978-01-01" @default.
- W2026645310 modified "2023-10-18" @default.
- W2026645310 title "UNUSUAL COURSES OF ACUTE LYMPHOCYTIC LEUKEMIA (ALL)" @default.
- W2026645310 doi "https://doi.org/10.1203/00006450-197801000-00062" @default.
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