Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026653670> ?p ?o ?g. }
- W2026653670 endingPage "238" @default.
- W2026653670 startingPage "231" @default.
- W2026653670 abstract "BackgroundPeripheral arterial disease (PAD) can be diagnosed noninvasively by segmental blood pressure measurement and calculating an ankle-brachial index (ABI) or toe-brachial index (TBI). The ABI is known to be unreliable in patients with vascular stiffness and fails to detect the early phase of arteriosclerotic development. The toe vessels are less susceptible to vessel stiffness, which makes the TBI useful. However, the diagnostic limits used in guidelines, clinical settings, and experimental studies vary substantially. This review provides an overview of the evidence supporting the clinical use of the TBI.MethodsA review of the literature identified studies reporting the use of the TBI regarding guideline recommendations, normal populations, correlations to angiographic findings, and prognostic implications.ResultsEight studies conducted in a normal population were identified, of which only one study used imaging techniques to rule out arterial stenosis. A reference value of 0.71 was estimated as the lowest limit of normal based on the weighted average in studies with preheating of the limbs. A further seven studies showed correlations of the TBI with angiographic findings. The TBI had a sensitivity of 90% to 100% and a specificity of 65% to 100% for the detection of vessel stenosis. Few studies investigated the value of the TBI as a prognostic marker for cardiovascular mortality and morbidity, and no firm conclusions could be made. Studies have, however, shown correlation between the TBI and comorbidities such as kidney disease, diabetes, and microvasculature disease.ConclusionsIn contrast to the well-defined and evidence-based limits of the ABI, the diagnostic criteria for a pathologic TBI remain ambiguous. Although several guidelines and reviews of PAD diagnostics recommend a TBI <0.70 as cutoff, it is not strictly evidence-based. The current literature is not sufficient to conclude a specific cutoff as diagnostic for PAD. The current studies in normal populations and the correlation with angiography are sparse, and additional trials are needed to further validate the limits. Large-scale trials are needed to establish the risk of morbidity and mortality for the various diagnostic limits of the TBI. Peripheral arterial disease (PAD) can be diagnosed noninvasively by segmental blood pressure measurement and calculating an ankle-brachial index (ABI) or toe-brachial index (TBI). The ABI is known to be unreliable in patients with vascular stiffness and fails to detect the early phase of arteriosclerotic development. The toe vessels are less susceptible to vessel stiffness, which makes the TBI useful. However, the diagnostic limits used in guidelines, clinical settings, and experimental studies vary substantially. This review provides an overview of the evidence supporting the clinical use of the TBI. A review of the literature identified studies reporting the use of the TBI regarding guideline recommendations, normal populations, correlations to angiographic findings, and prognostic implications. Eight studies conducted in a normal population were identified, of which only one study used imaging techniques to rule out arterial stenosis. A reference value of 0.71 was estimated as the lowest limit of normal based on the weighted average in studies with preheating of the limbs. A further seven studies showed correlations of the TBI with angiographic findings. The TBI had a sensitivity of 90% to 100% and a specificity of 65% to 100% for the detection of vessel stenosis. Few studies investigated the value of the TBI as a prognostic marker for cardiovascular mortality and morbidity, and no firm conclusions could be made. Studies have, however, shown correlation between the TBI and comorbidities such as kidney disease, diabetes, and microvasculature disease. In contrast to the well-defined and evidence-based limits of the ABI, the diagnostic criteria for a pathologic TBI remain ambiguous. Although several guidelines and reviews of PAD diagnostics recommend a TBI <0.70 as cutoff, it is not strictly evidence-based. The current literature is not sufficient to conclude a specific cutoff as diagnostic for PAD. The current studies in normal populations and the correlation with angiography are sparse, and additional trials are needed to further validate the limits. Large-scale trials are needed to establish the risk of morbidity and mortality for the various diagnostic limits of the TBI." @default.
- W2026653670 created "2016-06-24" @default.
- W2026653670 creator A5057819012 @default.
- W2026653670 creator A5058186502 @default.
- W2026653670 creator A5075993572 @default.
- W2026653670 date "2013-07-01" @default.
- W2026653670 modified "2023-10-13" @default.
- W2026653670 title "The toe-brachial index in the diagnosis of peripheral arterial disease" @default.
- W2026653670 cites W1861634206 @default.
- W2026653670 cites W1896777210 @default.
- W2026653670 cites W1963892836 @default.
- W2026653670 cites W1969253556 @default.
- W2026653670 cites W1970423201 @default.
- W2026653670 cites W1972141653 @default.
- W2026653670 cites W1973243470 @default.
- W2026653670 cites W1973293048 @default.
- W2026653670 cites W1976100739 @default.
- W2026653670 cites W1978285389 @default.
- W2026653670 cites W1981984652 @default.
- W2026653670 cites W1982392960 @default.
- W2026653670 cites W1989846252 @default.
- W2026653670 cites W1992749166 @default.
- W2026653670 cites W1994143966 @default.
- W2026653670 cites W1997355580 @default.
- W2026653670 cites W1998691431 @default.
- W2026653670 cites W2004754006 @default.
- W2026653670 cites W2005251975 @default.
- W2026653670 cites W2006077252 @default.
- W2026653670 cites W2018123909 @default.
- W2026653670 cites W2026800331 @default.
- W2026653670 cites W2028490375 @default.
- W2026653670 cites W2033188802 @default.
- W2026653670 cites W2038547095 @default.
- W2026653670 cites W2040196764 @default.
- W2026653670 cites W2048177968 @default.
- W2026653670 cites W2048526317 @default.
- W2026653670 cites W2049609108 @default.
- W2026653670 cites W2049808831 @default.
- W2026653670 cites W2053903565 @default.
- W2026653670 cites W2057763625 @default.
- W2026653670 cites W2062508201 @default.
- W2026653670 cites W2067197002 @default.
- W2026653670 cites W2068393325 @default.
- W2026653670 cites W2068399595 @default.
- W2026653670 cites W2068581370 @default.
- W2026653670 cites W2070284052 @default.
- W2026653670 cites W2074682040 @default.
- W2026653670 cites W2075061346 @default.
- W2026653670 cites W2079128771 @default.
- W2026653670 cites W2087512347 @default.
- W2026653670 cites W2087541472 @default.
- W2026653670 cites W2089946259 @default.
- W2026653670 cites W2097220938 @default.
- W2026653670 cites W2106343349 @default.
- W2026653670 cites W2106664741 @default.
- W2026653670 cites W2107638293 @default.
- W2026653670 cites W2122274177 @default.
- W2026653670 cites W2122891093 @default.
- W2026653670 cites W2124223124 @default.
- W2026653670 cites W2128191070 @default.
- W2026653670 cites W2128477063 @default.
- W2026653670 cites W2131984157 @default.
- W2026653670 cites W2134294665 @default.
- W2026653670 cites W2145214903 @default.
- W2026653670 cites W2145409946 @default.
- W2026653670 cites W2151318989 @default.
- W2026653670 cites W2153188402 @default.
- W2026653670 cites W2154443303 @default.
- W2026653670 cites W2156044035 @default.
- W2026653670 cites W2163106819 @default.
- W2026653670 cites W2163173787 @default.
- W2026653670 cites W2163369409 @default.
- W2026653670 cites W2163951953 @default.
- W2026653670 cites W2315243802 @default.
- W2026653670 cites W2567901815 @default.
- W2026653670 cites W2887712073 @default.
- W2026653670 cites W4230870013 @default.
- W2026653670 cites W4233748100 @default.
- W2026653670 cites W4236938366 @default.
- W2026653670 cites W4245614675 @default.
- W2026653670 doi "https://doi.org/10.1016/j.jvs.2013.03.044" @default.
- W2026653670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23688630" @default.
- W2026653670 hasPublicationYear "2013" @default.
- W2026653670 type Work @default.
- W2026653670 sameAs 2026653670 @default.
- W2026653670 citedByCount "172" @default.
- W2026653670 countsByYear W20266536702013 @default.
- W2026653670 countsByYear W20266536702014 @default.
- W2026653670 countsByYear W20266536702015 @default.
- W2026653670 countsByYear W20266536702016 @default.
- W2026653670 countsByYear W20266536702017 @default.
- W2026653670 countsByYear W20266536702018 @default.
- W2026653670 countsByYear W20266536702019 @default.
- W2026653670 countsByYear W20266536702020 @default.
- W2026653670 countsByYear W20266536702021 @default.
- W2026653670 countsByYear W20266536702022 @default.
- W2026653670 countsByYear W20266536702023 @default.
- W2026653670 crossrefType "journal-article" @default.