FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026654178> ?p ?o ?g. }

• W2026654178 endingPage "176" @default.
• W2026654178 startingPage "165" @default.
• W2026654178 abstract "The antioxidant activity of flavonoids has been suggested to contribute to several health benefits associated with the consumption of fruits and vegetables. Four flavonols - myricetin (M), quercetin (Q), kaempferol (K) and galangin (G), all with different numbers of hydroxyl moieties (-OH) - were examined for their antioxidant activity and cytotoxicity on human umbilical vein endothelial cells (HUVECs) and for their potential antiangiogenic and cell adhesion effects. The relative antioxidant capacity of these flavonols in cell culture medium (cell-free system) and their intracellular antioxidant activity were M = Q > K = G, which correlated respectively with the presence of 3, 2, 1 and 0 moieties of -OH on their B-ring. The higher the numbers of -OH moieties on the B-ring the less toxic the flavonol was to HUVEC, and the LD50 was determined as: M (100 microM) > Q (50 microM) > K (20 microM) > G (10 microM). These flavonols at approximately 0.5 LD50 doses suppressed the vascular endothelial growth factor (VEGF)-stimulated HUVEC tubular structure formation by: M (47%) > Q (37%) > K (15%) > G (14%), which was not linearly associated with their numbers of -OH moieties. However, the magnitude of flavonols' suppression of activated U937 monocytic cells adhesion to HUVEC was associated with the number of -OH moieties on the B-ring. This was prominent when U937 cells were pretreated with these flavonols. In contrast, the numbers of -OH moiety had no apparent influence on the adhesion or expression of adhesion molecules when activated HUVECs were pretreated with these flavonols. The presence of different numbers of -OH moieties on the B-ring of the flavonols may contribute to their antioxidant activity as well as their toxicity and may play an important role in their potency for biological action such as angiogenesis and immune-endothelial cell adhesion, which, respectively, are important processes in the development of cancer and atherosclerosis." @default.
• W2026654178 created "2016-06-24" @default.
• W2026654178 creator A5001814538 @default.
• W2026654178 creator A5015010508 @default.
• W2026654178 creator A5021809579 @default.
• W2026654178 creator A5060861040 @default.
• W2026654178 date "2006-03-01" @default.
• W2026654178 modified "2023-10-10" @default.
• W2026654178 title "Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion" @default.
• W2026654178 cites W124213883 @default.
• W2026654178 cites W1500360861 @default.
• W2026654178 cites W1964046231 @default.
• W2026654178 cites W1964968638 @default.
• W2026654178 cites W1967108152 @default.
• W2026654178 cites W1971127546 @default.
• W2026654178 cites W1974052637 @default.
• W2026654178 cites W1974805894 @default.
• W2026654178 cites W1975549382 @default.
• W2026654178 cites W1976392585 @default.
• W2026654178 cites W1986125832 @default.
• W2026654178 cites W1987606389 @default.
• W2026654178 cites W1995074694 @default.
• W2026654178 cites W1995963629 @default.
• W2026654178 cites W2000428769 @default.
• W2026654178 cites W2000783941 @default.
• W2026654178 cites W2007924591 @default.
• W2026654178 cites W2011666969 @default.
• W2026654178 cites W2017384386 @default.
• W2026654178 cites W2019590374 @default.
• W2026654178 cites W2020215197 @default.
• W2026654178 cites W2020349051 @default.
• W2026654178 cites W2020967224 @default.
• W2026654178 cites W2022040093 @default.
• W2026654178 cites W2026363454 @default.
• W2026654178 cites W2026402583 @default.
• W2026654178 cites W2034805981 @default.
• W2026654178 cites W2042458511 @default.
• W2026654178 cites W2057889917 @default.
• W2026654178 cites W2059415352 @default.
• W2026654178 cites W2061142443 @default.
• W2026654178 cites W2071068936 @default.
• W2026654178 cites W2074833031 @default.
• W2026654178 cites W2078316516 @default.
• W2026654178 cites W2080864890 @default.
• W2026654178 cites W2082589389 @default.
• W2026654178 cites W2086959952 @default.
• W2026654178 cites W2087434599 @default.
• W2026654178 cites W2088166099 @default.
• W2026654178 cites W2089649662 @default.
• W2026654178 cites W2092620381 @default.
• W2026654178 cites W2116060738 @default.
• W2026654178 cites W2117255510 @default.
• W2026654178 cites W2136495779 @default.
• W2026654178 cites W2138562665 @default.
• W2026654178 cites W2144868623 @default.
• W2026654178 cites W2150004127 @default.
• W2026654178 cites W2164931507 @default.
• W2026654178 cites W2317815683 @default.
• W2026654178 doi "https://doi.org/10.1016/j.jnutbio.2005.06.006" @default.
• W2026654178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16169200" @default.
• W2026654178 hasPublicationYear "2006" @default.
• W2026654178 type Work @default.
• W2026654178 sameAs 2026654178 @default.
• W2026654178 citedByCount "142" @default.
• W2026654178 countsByYear W20266541782012 @default.
• W2026654178 countsByYear W20266541782013 @default.
• W2026654178 countsByYear W20266541782014 @default.
• W2026654178 countsByYear W20266541782015 @default.
• W2026654178 countsByYear W20266541782016 @default.
• W2026654178 countsByYear W20266541782017 @default.
• W2026654178 countsByYear W20266541782018 @default.
• W2026654178 countsByYear W20266541782019 @default.
• W2026654178 countsByYear W20266541782020 @default.
• W2026654178 countsByYear W20266541782021 @default.
• W2026654178 countsByYear W20266541782022 @default.
• W2026654178 countsByYear W20266541782023 @default.
• W2026654178 crossrefType "journal-article" @default.
• W2026654178 hasAuthorship W2026654178A5001814538 @default.
• W2026654178 hasAuthorship W2026654178A5015010508 @default.
• W2026654178 hasAuthorship W2026654178A5021809579 @default.
• W2026654178 hasAuthorship W2026654178A5060861040 @default.
• W2026654178 hasConcept C185592680 @default.
• W2026654178 hasConcept C202751555 @default.
• W2026654178 hasConcept C2777302768 @default.
• W2026654178 hasConcept C2777411675 @default.
• W2026654178 hasConcept C2777810353 @default.
• W2026654178 hasConcept C2778004101 @default.
• W2026654178 hasConcept C2778173338 @default.
• W2026654178 hasConcept C2779106036 @default.
• W2026654178 hasConcept C2781263971 @default.
• W2026654178 hasConcept C55493867 @default.
• W2026654178 hasConcept C71240020 @default.
• W2026654178 hasConceptScore W2026654178C185592680 @default.
• W2026654178 hasConceptScore W2026654178C202751555 @default.
• W2026654178 hasConceptScore W2026654178C2777302768 @default.
• W2026654178 hasConceptScore W2026654178C2777411675 @default.
• W2026654178 hasConceptScore W2026654178C2777810353 @default.
• W2026654178 hasConceptScore W2026654178C2778004101 @default.

• next