FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026654295> ?p ?o ?g. }

• W2026654295 endingPage "440" @default.
• W2026654295 startingPage "428" @default.
• W2026654295 abstract "Seventeen cucurbitane-type triterpenoids, 1–17, including six new compounds, (23E)-3β,25-dihydroxy-7β-methoxycucurbita-5,23-dien-19-al (1), (23S*)-3β-hydroxy-7β,23-dimethoxycucurbita-5,24-dien-19-al (6), (23R*)-23-O-methylmomordicine IV (7), (25ξ)-26-hydroxymomordicoside L (8), 25-oxo-27-normomordicoside L (9), and 25-O-methylkaravilagenin D (12), were isolated from a MeOH extract of the leaves of Japanese Momordica charantia. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with literature. Compounds 1–17 were examined for their inhibitory effects on EpsteinBarr virus early antigen (EBV-EA) activation induced with 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, a known primary screening test for inhibitors of tumor promotion. Four compounds, 1, (23E)-3β,7β-dihydroxy-25-methoxycucurbita-5,23-dien-19-al (2), karavilagenin D (11), and 12, showed potent inhibitory effects on EBV-EA induction with IC50 values in the range of 242–264 mol ratio/32 pmol TPA. In addition, compounds 1 and 11 exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as a promoter. Furthermore, upon evaluation of the cytotoxic activities of compounds 1–17 against human cancer cell lines, compounds 2, 5–7, 9, and 14 showed potent activities against HL60 cell line, and compound 2 against SK-BR-3 cell line." @default.
• W2026654295 created "2016-06-24" @default.
• W2026654295 creator A5025863828 @default.
• W2026654295 creator A5030712022 @default.
• W2026654295 creator A5032322911 @default.
• W2026654295 creator A5042626675 @default.
• W2026654295 creator A5054691687 @default.
• W2026654295 creator A5070676743 @default.
• W2026654295 creator A5071996788 @default.
• W2026654295 creator A5073501391 @default.
• W2026654295 creator A5077714201 @default.
• W2026654295 creator A5080805451 @default.
• W2026654295 date "2012-02-01" @default.
• W2026654295 modified "2023-10-11" @default.
• W2026654295 title "Cucurbitane Triterpenoids from the Leaves of Momordica charantia, and Their Cancer Chemopreventive Effects and Cytotoxicities" @default.
• W2026654295 cites W1517828413 @default.
• W2026654295 cites W1946915776 @default.
• W2026654295 cites W1977251824 @default.
• W2026654295 cites W1978474729 @default.
• W2026654295 cites W1979099108 @default.
• W2026654295 cites W1979665552 @default.
• W2026654295 cites W1981090141 @default.
• W2026654295 cites W1988552013 @default.
• W2026654295 cites W2002967339 @default.
• W2026654295 cites W2020720041 @default.
• W2026654295 cites W2021717312 @default.
• W2026654295 cites W2022027556 @default.
• W2026654295 cites W2036238650 @default.
• W2026654295 cites W2037431488 @default.
• W2026654295 cites W2050056852 @default.
• W2026654295 cites W2052009035 @default.
• W2026654295 cites W2053170269 @default.
• W2026654295 cites W2065767645 @default.
• W2026654295 cites W2074803395 @default.
• W2026654295 cites W2086029126 @default.
• W2026654295 cites W2086772052 @default.
• W2026654295 cites W2087666908 @default.
• W2026654295 cites W2092675819 @default.
• W2026654295 cites W2093288975 @default.
• W2026654295 cites W2112224922 @default.
• W2026654295 cites W2138545754 @default.
• W2026654295 cites W2315853021 @default.
• W2026654295 cites W2324936571 @default.
• W2026654295 cites W2330623776 @default.
• W2026654295 cites W2949692026 @default.
• W2026654295 doi "https://doi.org/10.1002/cbdv.201100142" @default.
• W2026654295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22344919" @default.
• W2026654295 hasPublicationYear "2012" @default.
• W2026654295 type Work @default.
• W2026654295 sameAs 2026654295 @default.
• W2026654295 citedByCount "38" @default.
• W2026654295 countsByYear W20266542952012 @default.
• W2026654295 countsByYear W20266542952013 @default.
• W2026654295 countsByYear W20266542952014 @default.
• W2026654295 countsByYear W20266542952015 @default.
• W2026654295 countsByYear W20266542952016 @default.
• W2026654295 countsByYear W20266542952017 @default.
• W2026654295 countsByYear W20266542952018 @default.
• W2026654295 countsByYear W20266542952019 @default.
• W2026654295 countsByYear W20266542952020 @default.
• W2026654295 countsByYear W20266542952021 @default.
• W2026654295 countsByYear W20266542952022 @default.
• W2026654295 crossrefType "journal-article" @default.
• W2026654295 hasAuthorship W2026654295A5025863828 @default.
• W2026654295 hasAuthorship W2026654295A5030712022 @default.
• W2026654295 hasAuthorship W2026654295A5032322911 @default.
• W2026654295 hasAuthorship W2026654295A5042626675 @default.
• W2026654295 hasAuthorship W2026654295A5054691687 @default.
• W2026654295 hasAuthorship W2026654295A5070676743 @default.
• W2026654295 hasAuthorship W2026654295A5071996788 @default.
• W2026654295 hasAuthorship W2026654295A5073501391 @default.
• W2026654295 hasAuthorship W2026654295A5077714201 @default.
• W2026654295 hasAuthorship W2026654295A5080805451 @default.
• W2026654295 hasConcept C104317684 @default.
• W2026654295 hasConcept C142724271 @default.
• W2026654295 hasConcept C150903083 @default.
• W2026654295 hasConcept C154317977 @default.
• W2026654295 hasConcept C161790260 @default.
• W2026654295 hasConcept C16232356 @default.
• W2026654295 hasConcept C185592680 @default.
• W2026654295 hasConcept C202751555 @default.
• W2026654295 hasConcept C204787440 @default.
• W2026654295 hasConcept C206103511 @default.
• W2026654295 hasConcept C207001950 @default.
• W2026654295 hasConcept C2775888733 @default.
• W2026654295 hasConcept C2778686829 @default.
• W2026654295 hasConcept C2778938436 @default.
• W2026654295 hasConcept C2780122803 @default.
• W2026654295 hasConcept C2780527577 @default.
• W2026654295 hasConcept C54355233 @default.
• W2026654295 hasConcept C55493867 @default.
• W2026654295 hasConcept C555283112 @default.
• W2026654295 hasConcept C556039675 @default.
• W2026654295 hasConcept C71240020 @default.
• W2026654295 hasConcept C71924100 @default.
• W2026654295 hasConcept C81885089 @default.
• W2026654295 hasConcept C86803240 @default.
• W2026654295 hasConceptScore W2026654295C104317684 @default.

• next