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- W2026661808 abstract "Eleven 1-(4-substituted α-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(α-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release adn lysed the islet β cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas. Onze 1-(α-arylaminobenzylidène)thiosemicarbazides 1 ainsi que les semicarbazones homologues 2 ont été synthétisées et testées pour leurs propriétés inhibitrices sur les sécrétions des îlots de Langerhans. Seules les thiosemicarbazones 1 inhibent la sécrétion d'insuline et de glucagon: celle de somatostatine persiste. La molécule la plus active est la 1-(α-anilino-4-méthylbenzylidène)thiosemicarbazide 1f. La présence de sulfate de zinc supprime les effets inhibiteurs et cytotoxiques de 1f. De tels composés pourraient avoir une application dans le traitement des insulinomes." @default.
- W2026661808 created "2016-06-24" @default.
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- W2026661808 date "1991-04-01" @default.
- W2026661808 modified "2023-10-05" @default.
- W2026661808 title "Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives" @default.
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- W2026661808 doi "https://doi.org/10.1016/0223-5234(91)90059-v" @default.
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