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• W2026662023 endingPage "757" @default.
• W2026662023 startingPage "748" @default.
• W2026662023 abstract "This work uses ATR-FTIR spectroscopic imaging to study the dissolution of delayed release and pH resistant compressed coating pharmaceutical tablets. Tablets with an inner core and outer shell were constructed using a custom designed compaction cell. The core of the delayed release tablets consisted of hydroxypropyl methylcellulose (HPMC) and caffeine. The shell consisted of microcrystalline cellulose (MCC) and glucose. The core of the pH resistant formulations was an ibuprofen and PEG melt and the shell was constructed from HPMC and a basic buffer. UV/vis spectroscopy was used to monitor the lag-time of drug release and visible optical video imaging was used as a complementary imaging technique with a larger field of view. Two delayed release mechanisms were established. For tablets with soluble shell sections, lag-time was dependent upon rapid shell dissolution. For tablets with less soluble shells, the lag-time was controlled by the rate of dissolution medium ingress through the shell and the subsequent expansion of the wet HPMC core. The pH resistant formulations prevented crystallization of the ibuprofen in the core during dissolution despite an acidic dissolution medium. FTIR imaging produced important information about the physical and chemical processes occurring at the interface between tablet sections during dissolution." @default.
• W2026662023 created "2016-06-24" @default.
• W2026662023 creator A5042342502 @default.
• W2026662023 creator A5044061455 @default.
• W2026662023 creator A5064673776 @default.
• W2026662023 date "2013-03-01" @default.
• W2026662023 modified "2023-09-26" @default.
• W2026662023 title "Dissolution of tablet-in-tablet formulations studied with ATR-FTIR spectroscopic imaging" @default.
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• W2026662023 doi "https://doi.org/10.1016/j.ejps.2012.12.022" @default.
• W2026662023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23291036" @default.
• W2026662023 hasPublicationYear "2013" @default.
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