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- W2026664590 abstract "To the Editor: I read with interest the paper by Lawrence et al on the use of selective estrogen receptor modulators (SERMS) in the treatment of adolescents with gynecomastia.1Lawrence S.E. Faught K.A. Vethamuthu J. et al.Beneficial effects of raloxifene and tamoxifene in the treatment of pubertal gynecomastia.J Pediatr. 2004; 145: 71-76Abstract Full Text Full Text PDF PubMed Scopus (105) Google Scholar Although this was an uncontrolled, retrospective chart review, the implications of the data are interesting. I am, however, concerned that there is no mention of proper obtaining of written informed consent. The authors state that, “The choice of therapy was based on current clinical practice in the clinic with increasing trend over time toward treatment with tamoxifen and in later years, with raloxifene.” To my knowledge, neither drug is presently approved in the United States or in Canada for the use in males with gynecomastia, hence the systematic treatment of male youth with SERMS for research purposes certainly requires informed consent. If none was obtained, I think the authors should at the very least state whether their IRB exempted them from written informed consent. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastiaThe Journal of PediatricsVol. 145Issue 1PreviewTo assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. Full-Text PDF ReplyThe Journal of PediatricsVol. 146Issue 4PreviewTo the Editor: Full-Text PDF" @default.
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- W2026664590 date "2005-04-01" @default.
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- W2026664590 title "Treatment of adolescents with gynecomastia" @default.
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- W2026664590 doi "https://doi.org/10.1016/j.jpeds.2004.10.048" @default.
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