FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026666590> ?p ?o ?g. }

• W2026666590 endingPage "83" @default.
• W2026666590 startingPage "73" @default.
• W2026666590 abstract "LQB 118 is a pterocarpanquinone compound synthesized by our group. It has already been shown that it acts against different leukemia cell lines. However, little is known about the pathway through which this compound induces the death of these cells. In this work, we analyzed the cell death process induced by LQB 118 in K562, a chronic myeloid leukemia cell line, and in Jurkat, a lymphoblastic acute leukemia cell line. For this, we carried out a cell viability assay by MTT, an apoptosis/necrosis assay through the annexin/propidium iodide label, cell cycle by flow cytometry, assessed changes in the mitochondrial membrane potential using DiOC6(3), cytoplasmic calcium analysis by Fluo-3-AM, and a caspase-9 and caspase-12 activity assay. We found that LQB 118 induced apoptosis in both cell lines, measuring caspase-12 and caspase-9 activation, phosphatidylserine externalization, and DNA fragmentation. The compound induced an increase in cytoplasmic calcium on both cell lines. However, the compound could only induce mitochondrial membrane depolarization on K562 cells. Our data show that LQB 118 may have potential therapeutic value for leukemia, being able to overcome multiple resistance mechanisms." @default.
• W2026666590 created "2016-06-24" @default.
• W2026666590 creator A5015549428 @default.
• W2026666590 creator A5051377893 @default.
• W2026666590 creator A5069051386 @default.
• W2026666590 creator A5069195198 @default.
• W2026666590 date "2013-01-01" @default.
• W2026666590 modified "2023-10-01" @default.
• W2026666590 title "The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway" @default.
• W2026666590 cites W1211118294 @default.
• W2026666590 cites W1905806846 @default.
• W2026666590 cites W1964847265 @default.
• W2026666590 cites W1967544359 @default.
• W2026666590 cites W1969858812 @default.
• W2026666590 cites W1972239832 @default.
• W2026666590 cites W1983339648 @default.
• W2026666590 cites W1989052616 @default.
• W2026666590 cites W1990631589 @default.
• W2026666590 cites W1991958238 @default.
• W2026666590 cites W2017319763 @default.
• W2026666590 cites W2022582116 @default.
• W2026666590 cites W2028574074 @default.
• W2026666590 cites W2054691377 @default.
• W2026666590 cites W2062166266 @default.
• W2026666590 cites W2067169557 @default.
• W2026666590 cites W2069820860 @default.
• W2026666590 cites W2083009331 @default.
• W2026666590 cites W2089185262 @default.
• W2026666590 cites W2099305407 @default.
• W2026666590 cites W2100769394 @default.
• W2026666590 cites W2109162211 @default.
• W2026666590 cites W2116255975 @default.
• W2026666590 cites W2130517611 @default.
• W2026666590 cites W2161824849 @default.
• W2026666590 cites W2950321002 @default.
• W2026666590 doi "https://doi.org/10.1097/cad.0b013e3283592da8" @default.
• W2026666590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22960938" @default.
• W2026666590 hasPublicationYear "2013" @default.
• W2026666590 type Work @default.
• W2026666590 sameAs 2026666590 @default.
• W2026666590 citedByCount "15" @default.
• W2026666590 countsByYear W20266665902014 @default.
• W2026666590 countsByYear W20266665902017 @default.
• W2026666590 countsByYear W20266665902018 @default.
• W2026666590 countsByYear W20266665902019 @default.
• W2026666590 countsByYear W20266665902020 @default.
• W2026666590 countsByYear W20266665902021 @default.
• W2026666590 countsByYear W20266665902023 @default.
• W2026666590 crossrefType "journal-article" @default.
• W2026666590 hasAuthorship W2026666590A5015549428 @default.
• W2026666590 hasAuthorship W2026666590A5051377893 @default.
• W2026666590 hasAuthorship W2026666590A5069051386 @default.
• W2026666590 hasAuthorship W2026666590A5069195198 @default.
• W2026666590 hasConcept C153911025 @default.
• W2026666590 hasConcept C158617107 @default.
• W2026666590 hasConcept C171122931 @default.
• W2026666590 hasConcept C179464577 @default.
• W2026666590 hasConcept C185592680 @default.
• W2026666590 hasConcept C190283241 @default.
• W2026666590 hasConcept C203014093 @default.
• W2026666590 hasConcept C2775934118 @default.
• W2026666590 hasConcept C2776090121 @default.
• W2026666590 hasConcept C2778729363 @default.
• W2026666590 hasConcept C31573885 @default.
• W2026666590 hasConcept C43759708 @default.
• W2026666590 hasConcept C502942594 @default.
• W2026666590 hasConcept C53227056 @default.
• W2026666590 hasConcept C54355233 @default.
• W2026666590 hasConcept C55493867 @default.
• W2026666590 hasConcept C81885089 @default.
• W2026666590 hasConcept C86803240 @default.
• W2026666590 hasConcept C88634738 @default.
• W2026666590 hasConcept C8891405 @default.
• W2026666590 hasConcept C95444343 @default.
• W2026666590 hasConceptScore W2026666590C153911025 @default.
• W2026666590 hasConceptScore W2026666590C158617107 @default.
• W2026666590 hasConceptScore W2026666590C171122931 @default.
• W2026666590 hasConceptScore W2026666590C179464577 @default.
• W2026666590 hasConceptScore W2026666590C185592680 @default.
• W2026666590 hasConceptScore W2026666590C190283241 @default.
• W2026666590 hasConceptScore W2026666590C203014093 @default.
• W2026666590 hasConceptScore W2026666590C2775934118 @default.
• W2026666590 hasConceptScore W2026666590C2776090121 @default.
• W2026666590 hasConceptScore W2026666590C2778729363 @default.
• W2026666590 hasConceptScore W2026666590C31573885 @default.
• W2026666590 hasConceptScore W2026666590C43759708 @default.
• W2026666590 hasConceptScore W2026666590C502942594 @default.
• W2026666590 hasConceptScore W2026666590C53227056 @default.
• W2026666590 hasConceptScore W2026666590C54355233 @default.
• W2026666590 hasConceptScore W2026666590C55493867 @default.
• W2026666590 hasConceptScore W2026666590C81885089 @default.
• W2026666590 hasConceptScore W2026666590C86803240 @default.
• W2026666590 hasConceptScore W2026666590C88634738 @default.
• W2026666590 hasConceptScore W2026666590C8891405 @default.
• W2026666590 hasConceptScore W2026666590C95444343 @default.
• W2026666590 hasIssue "1" @default.
• W2026666590 hasLocation W20266665901 @default.
• W2026666590 hasLocation W20266665902 @default.

• next