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- W2026677444 abstract "Twenty-five muscle biopsies were obtained from 20 infants and children ranging in age from one week to 14 years by percutaneous technique, using Bergstrom and modified Bergstrom needles ranging from 3.0 to 5.5 mm diameter. The standard Bergstrom needle was altered to reduce the distance from tip to cutting window making it more suitable for small infants. Adequate tissue samples for histochemical and ultrastructural evaluation were obtained in all but one biopsy. The procedure was performed using local anesthetic, was well tolerated and no complications were observed in spite of prolonged PT and PTT on 4 occasions. The only morbidity was moderate discomfort in several patients for about 24 hours. Diagnoses included congenital myopathies (5), dystrophies (2), Reye's syndrome (4), polymyositis (1) and spinal muscular atrophy (1). Tissue for ultrastructural studies was pinned prior to fixation in glutarldehyde, the remainder was oriented for frozen transverse and longitudinal sections using a dissecting microscope. Unless focal disease is present the quadriceps muscle is the preferred site for biopsy, particularly in infants. The percutaneous muscle biopsy should be considered the procedure of choice in infants and children unless a larger tissue sample is needed for metabolic studies." @default.
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- W2026677444 date "1981-04-01" @default.
- W2026677444 modified "2023-10-17" @default.
- W2026677444 title "1568 PERCUTANEOUS MUSCLE BIOPSY IN PEDIATRIC-AGE PATIENTS" @default.
- W2026677444 doi "https://doi.org/10.1203/00006450-198104001-01585" @default.
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