FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026685188> ?p ?o ?g. }

• W2026685188 endingPage "698" @default.
• W2026685188 startingPage "687" @default.
• W2026685188 abstract "5-androstenediol (5-AED) has been advanced as a possible countermeasure for treating the haematological component of acute radiation syndrome (ARS). It has been used in animal models to stimulate both innate and adaptive immunity and treat infection and radiation-induced immune suppression. We here report on the safety, tolerability and haematologic activity of 5-AED in four double-blinded, randomized, placebo-controlled studies on healthy adults including elderly subjects. A 5-AED injectable suspension formulation (NEUMUNE) or placebo was administered intramuscularly as either a single injection, or once daily for five consecutive days at doses of 50, 100, 200 or 400 mg. Subjects (n = 129) were randomized to receive NEUMUNE (n = 95) or the placebo (n = 34). NEUMUNE was generally well-tolerated; the most frequent adverse events were local injection site reactions (n = 104, 81%) that were transient, dose-volume dependent, mild to moderate in severity, and that resolved over the course of the study. Blood chemistries revealed a transient increase (up to 28%) in creatine phosphokinase and C-reactive protein levels consistent with intramuscular injection and injection site irritation. The blood concentration profile of 5-AED is consistent with a depot formulation that increases in disproportionate increments following each dose. NEUMUNE significantly increased circulating neutrophils (p < 0.001) and platelets (p < 0.001) in the peripheral blood of adult and elderly subjects. A dose-response relationship was identified. Findings suggest that parenteral administration of 5-AED in aqueous suspension may be a safe and effective means to stimulate innate immunity and alleviate neutropenia and thrombocytopenia associated with ARS." @default.
• W2026685188 created "2016-06-24" @default.
• W2026685188 creator A5001463865 @default.
• W2026685188 creator A5022382417 @default.
• W2026685188 creator A5023186104 @default.
• W2026685188 creator A5026194032 @default.
• W2026685188 creator A5026873454 @default.
• W2026685188 creator A5031736192 @default.
• W2026685188 creator A5031736547 @default.
• W2026685188 creator A5032684836 @default.
• W2026685188 creator A5053699584 @default.
• W2026685188 creator A5067179773 @default.
• W2026685188 creator A5085488706 @default.
• W2026685188 date "2010-12-01" @default.
• W2026685188 modified "2023-09-25" @default.
• W2026685188 title "Preliminary clinical findings on NEUMUNE as a potential treatment for acute radiation syndrome" @default.
• W2026685188 cites W1908287883 @default.
• W2026685188 cites W1972574171 @default.
• W2026685188 cites W1973015516 @default.
• W2026685188 cites W1979898922 @default.
• W2026685188 cites W1980783315 @default.
• W2026685188 cites W1981091899 @default.
• W2026685188 cites W1981442420 @default.
• W2026685188 cites W1982005589 @default.
• W2026685188 cites W1988463112 @default.
• W2026685188 cites W1989147755 @default.
• W2026685188 cites W1992061940 @default.
• W2026685188 cites W2002629699 @default.
• W2026685188 cites W2016722329 @default.
• W2026685188 cites W2032176427 @default.
• W2026685188 cites W2038377549 @default.
• W2026685188 cites W2049640406 @default.
• W2026685188 cites W2050558004 @default.
• W2026685188 cites W2077845621 @default.
• W2026685188 cites W2079167470 @default.
• W2026685188 cites W2089825648 @default.
• W2026685188 cites W2094225565 @default.
• W2026685188 cites W2096104385 @default.
• W2026685188 cites W2100391842 @default.
• W2026685188 cites W2119573232 @default.
• W2026685188 cites W2152960123 @default.
• W2026685188 cites W2156781497 @default.
• W2026685188 cites W2165554016 @default.
• W2026685188 cites W2169422711 @default.
• W2026685188 cites W2173072057 @default.
• W2026685188 cites W2296928753 @default.
• W2026685188 cites W2341557816 @default.
• W2026685188 cites W2398866481 @default.
• W2026685188 cites W28446134 @default.
• W2026685188 cites W301040576 @default.
• W2026685188 cites W4234255376 @default.
• W2026685188 cites W4238516327 @default.
• W2026685188 cites W4246393526 @default.
• W2026685188 cites W4246713710 @default.
• W2026685188 cites W8506351 @default.
• W2026685188 cites W92133935 @default.
• W2026685188 doi "https://doi.org/10.1088/0952-4746/30/4/004" @default.
• W2026685188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21149931" @default.
• W2026685188 hasPublicationYear "2010" @default.
• W2026685188 type Work @default.
• W2026685188 sameAs 2026685188 @default.
• W2026685188 citedByCount "16" @default.
• W2026685188 countsByYear W20266851882012 @default.
• W2026685188 countsByYear W20266851882013 @default.
• W2026685188 countsByYear W20266851882014 @default.
• W2026685188 countsByYear W20266851882015 @default.
• W2026685188 countsByYear W20266851882017 @default.
• W2026685188 countsByYear W20266851882019 @default.
• W2026685188 countsByYear W20266851882020 @default.
• W2026685188 crossrefType "journal-article" @default.
• W2026685188 hasAuthorship W2026685188A5001463865 @default.
• W2026685188 hasAuthorship W2026685188A5022382417 @default.
• W2026685188 hasAuthorship W2026685188A5023186104 @default.
• W2026685188 hasAuthorship W2026685188A5026194032 @default.
• W2026685188 hasAuthorship W2026685188A5026873454 @default.
• W2026685188 hasAuthorship W2026685188A5031736192 @default.
• W2026685188 hasAuthorship W2026685188A5031736547 @default.
• W2026685188 hasAuthorship W2026685188A5032684836 @default.
• W2026685188 hasAuthorship W2026685188A5053699584 @default.
• W2026685188 hasAuthorship W2026685188A5067179773 @default.
• W2026685188 hasAuthorship W2026685188A5085488706 @default.
• W2026685188 hasConcept C126322002 @default.
• W2026685188 hasConcept C142724271 @default.
• W2026685188 hasConcept C197934379 @default.
• W2026685188 hasConcept C204787440 @default.
• W2026685188 hasConcept C27081682 @default.
• W2026685188 hasConcept C2777063308 @default.
• W2026685188 hasConcept C2778375690 @default.
• W2026685188 hasConcept C29730261 @default.
• W2026685188 hasConcept C42219234 @default.
• W2026685188 hasConcept C71924100 @default.
• W2026685188 hasConceptScore W2026685188C126322002 @default.
• W2026685188 hasConceptScore W2026685188C142724271 @default.
• W2026685188 hasConceptScore W2026685188C197934379 @default.
• W2026685188 hasConceptScore W2026685188C204787440 @default.
• W2026685188 hasConceptScore W2026685188C27081682 @default.
• W2026685188 hasConceptScore W2026685188C2777063308 @default.
• W2026685188 hasConceptScore W2026685188C2778375690 @default.

• next