Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026692702> ?p ?o ?g. }
- W2026692702 endingPage "1638" @default.
- W2026692702 startingPage "1638" @default.
- W2026692702 abstract "Cells residing in a microenvironment interact with the extracellular matrix (ECM) and neighboring cells. The ECM built from biomacromolecules often includes nanotopography. Through the ECM, interstitial flows facilitate transport of nutrients and play an important role in tissue maintenance and pathobiology. To create a microenvironment that can incorporate both nanotopography and flow for studies of cell–matrix interactions, we fabricated microfluidic channels endowed with nanopatterns suitable for dynamic culture. Using polymer thin film technology, we developed a versatile stitching technique to generate a large area of nanopatterned surface and a simple microtransfer assembly technique to assemble polydimethylsiloxane-based microfluidics. The cellular study showed that both nanotopography and fluid shear stress played a significant role in adhesion, spreading, and migration of human mesenchymal stem cells. The orientation and deformation of cytoskeleton and nuclei were regulated through the interplay of these two cues. The nanostructured microfluidic platform provides a useful tool to promote the fundamental understanding of cell–matrix interactions and may be used to regulate the fate of stem cells." @default.
- W2026692702 created "2016-06-24" @default.
- W2026692702 creator A5025959279 @default.
- W2026692702 creator A5029484872 @default.
- W2026692702 creator A5034678705 @default.
- W2026692702 creator A5050822671 @default.
- W2026692702 creator A5057130039 @default.
- W2026692702 date "2011-01-01" @default.
- W2026692702 modified "2023-09-25" @default.
- W2026692702 title "Engineering of a microfluidic cell culture platform embedded with nanoscale features" @default.
- W2026692702 cites W1965933207 @default.
- W2026692702 cites W1967474814 @default.
- W2026692702 cites W1972436525 @default.
- W2026692702 cites W1974416081 @default.
- W2026692702 cites W1986224722 @default.
- W2026692702 cites W1993799862 @default.
- W2026692702 cites W1994538451 @default.
- W2026692702 cites W1998454830 @default.
- W2026692702 cites W2000000908 @default.
- W2026692702 cites W2001591135 @default.
- W2026692702 cites W2008681436 @default.
- W2026692702 cites W2015979204 @default.
- W2026692702 cites W2018999951 @default.
- W2026692702 cites W2024971068 @default.
- W2026692702 cites W2026872383 @default.
- W2026692702 cites W2026908430 @default.
- W2026692702 cites W2026917510 @default.
- W2026692702 cites W2030509793 @default.
- W2026692702 cites W2032365341 @default.
- W2026692702 cites W2037537680 @default.
- W2026692702 cites W2038082227 @default.
- W2026692702 cites W2038722569 @default.
- W2026692702 cites W2039001850 @default.
- W2026692702 cites W2043098921 @default.
- W2026692702 cites W2043128020 @default.
- W2026692702 cites W2049854165 @default.
- W2026692702 cites W2052862499 @default.
- W2026692702 cites W2057564766 @default.
- W2026692702 cites W2058096164 @default.
- W2026692702 cites W2062712545 @default.
- W2026692702 cites W2063257376 @default.
- W2026692702 cites W2071311642 @default.
- W2026692702 cites W2071364594 @default.
- W2026692702 cites W2073795835 @default.
- W2026692702 cites W2076159213 @default.
- W2026692702 cites W2078782272 @default.
- W2026692702 cites W2081875458 @default.
- W2026692702 cites W2083838484 @default.
- W2026692702 cites W2105072296 @default.
- W2026692702 cites W2106829766 @default.
- W2026692702 cites W2112346252 @default.
- W2026692702 cites W2114661172 @default.
- W2026692702 cites W2131507486 @default.
- W2026692702 cites W2135335836 @default.
- W2026692702 cites W2144023435 @default.
- W2026692702 cites W2147208281 @default.
- W2026692702 cites W2148366851 @default.
- W2026692702 cites W2149893376 @default.
- W2026692702 cites W2158429263 @default.
- W2026692702 cites W2162452588 @default.
- W2026692702 cites W2172002964 @default.
- W2026692702 cites W2506683419 @default.
- W2026692702 cites W4246818002 @default.
- W2026692702 cites W4252568416 @default.
- W2026692702 doi "https://doi.org/10.1039/c0lc00736f" @default.
- W2026692702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21442110" @default.
- W2026692702 hasPublicationYear "2011" @default.
- W2026692702 type Work @default.
- W2026692702 sameAs 2026692702 @default.
- W2026692702 citedByCount "59" @default.
- W2026692702 countsByYear W20266927022012 @default.
- W2026692702 countsByYear W20266927022013 @default.
- W2026692702 countsByYear W20266927022014 @default.
- W2026692702 countsByYear W20266927022015 @default.
- W2026692702 countsByYear W20266927022016 @default.
- W2026692702 countsByYear W20266927022017 @default.
- W2026692702 countsByYear W20266927022018 @default.
- W2026692702 countsByYear W20266927022019 @default.
- W2026692702 countsByYear W20266927022020 @default.
- W2026692702 countsByYear W20266927022021 @default.
- W2026692702 countsByYear W20266927022022 @default.
- W2026692702 countsByYear W20266927022023 @default.
- W2026692702 crossrefType "journal-article" @default.
- W2026692702 hasAuthorship W2026692702A5025959279 @default.
- W2026692702 hasAuthorship W2026692702A5029484872 @default.
- W2026692702 hasAuthorship W2026692702A5034678705 @default.
- W2026692702 hasAuthorship W2026692702A5050822671 @default.
- W2026692702 hasAuthorship W2026692702A5057130039 @default.
- W2026692702 hasConcept C159985019 @default.
- W2026692702 hasConcept C171250308 @default.
- W2026692702 hasConcept C189165786 @default.
- W2026692702 hasConcept C192562407 @default.
- W2026692702 hasConcept C198826908 @default.
- W2026692702 hasConcept C2777803738 @default.
- W2026692702 hasConcept C2779849746 @default.
- W2026692702 hasConcept C84416704 @default.
- W2026692702 hasConcept C85789140 @default.
- W2026692702 hasConcept C8673954 @default.