FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026703040> ?p ?o ?g. }

• W2026703040 endingPage "192" @default.
• W2026703040 startingPage "179" @default.
• W2026703040 abstract "Exploiting molecules and pathways important in developmental axon behaviour may offer new insights into regenerative behaviour of adult peripheral neurons after injury. In previous work, we have provided evidence that inhibition or knockdown of PTEN (phosphatase and tensin homolog deleted on chromosome ten) dramatically increases adult peripheral axon outgrowth, especially in preconditioned neurons (Christie et al., 2010). PTEN appears to operate as an endogenous brake to regeneration. Recent reports from Drinjakovic et al. (2010) have highlighted a role for the ubiquitin proteasome system (UPS) during neurite outgrowth in developing Xenopus retinal ganglion cells. Specifically, disruption of the UPS E3 ligase Nedd4 (neural precursor cell‐expressed developmentally down-regulated protein 4) inhibited neurite branching through up-regulation of PTEN. We explored the potential role of Nedd4 in the peripheral neurons of adult rat dorsal root ganglia (DRG), particularly its impact on regenerative behaviour. Global inhibition of the UPS in vitro was associated with a severe decrease in neurite branching, both in preconditioned (injured) and control DRG sensory neurons . These involved neurons however maintained or qualitatively increased their PTEN expression, suggesting ongoing PTEN activity during UPS inhibition. Considering component's of UPS more specifically, Nedd4 co-localized with PTEN within sensory neurons in vivo and in vitro . Nedd4 also co-localized with PTEN and NF200 labelled regenerating axons at the injury site in the periphery following a 3 day sciatic nerve cut. A significant role for this unique co-expression was observed with fluorescently tagged siRNA inhibition of Nedd4, which decreased neurite outgrowth , an impact associated with greater expression of PTEN and that was completely reversed with application of a PTEN inhibitor. Overall, our results suggest an important role for Nedd4 regulation of PTEN in the response of peripheral neurons to injury. By degrading PTEN among other potential actions, Nedd4 supports axonal outgrowth whereas its inhibition facilitates PTEN inhibition of regeneration." @default.
• W2026703040 created "2016-06-24" @default.
• W2026703040 creator A5000062644 @default.
• W2026703040 creator A5035802220 @default.
• W2026703040 creator A5063767450 @default.
• W2026703040 date "2012-06-01" @default.
• W2026703040 modified "2023-10-18" @default.
• W2026703040 title "Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN" @default.
• W2026703040 cites W1510919372 @default.
• W2026703040 cites W1531652687 @default.
• W2026703040 cites W1595234035 @default.
• W2026703040 cites W1618653001 @default.
• W2026703040 cites W1956978115 @default.
• W2026703040 cites W1973140160 @default.
• W2026703040 cites W1973606440 @default.
• W2026703040 cites W1984817629 @default.
• W2026703040 cites W1986786130 @default.
• W2026703040 cites W1988141599 @default.
• W2026703040 cites W1996468220 @default.
• W2026703040 cites W1998366631 @default.
• W2026703040 cites W2000432680 @default.
• W2026703040 cites W2004538934 @default.
• W2026703040 cites W2006628865 @default.
• W2026703040 cites W2015926136 @default.
• W2026703040 cites W2036950807 @default.
• W2026703040 cites W2043423644 @default.
• W2026703040 cites W2047385780 @default.
• W2026703040 cites W2048919164 @default.
• W2026703040 cites W2053000720 @default.
• W2026703040 cites W2054023762 @default.
• W2026703040 cites W2061822901 @default.
• W2026703040 cites W2062104023 @default.
• W2026703040 cites W2065701510 @default.
• W2026703040 cites W2068427129 @default.
• W2026703040 cites W2073795788 @default.
• W2026703040 cites W2080214286 @default.
• W2026703040 cites W2081206164 @default.
• W2026703040 cites W2085001027 @default.
• W2026703040 cites W2086444954 @default.
• W2026703040 cites W2094215712 @default.
• W2026703040 cites W2094598036 @default.
• W2026703040 cites W2099658407 @default.
• W2026703040 cites W2120485521 @default.
• W2026703040 cites W2127202058 @default.
• W2026703040 cites W2138247439 @default.
• W2026703040 cites W2158021569 @default.
• W2026703040 cites W2164036959 @default.
• W2026703040 doi "https://doi.org/10.1016/j.mcn.2012.04.006" @default.
• W2026703040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22561198" @default.
• W2026703040 hasPublicationYear "2012" @default.
• W2026703040 type Work @default.
• W2026703040 sameAs 2026703040 @default.
• W2026703040 citedByCount "37" @default.
• W2026703040 countsByYear W20267030402013 @default.
• W2026703040 countsByYear W20267030402014 @default.
• W2026703040 countsByYear W20267030402015 @default.
• W2026703040 countsByYear W20267030402016 @default.
• W2026703040 countsByYear W20267030402017 @default.
• W2026703040 countsByYear W20267030402018 @default.
• W2026703040 countsByYear W20267030402019 @default.
• W2026703040 countsByYear W20267030402020 @default.
• W2026703040 countsByYear W20267030402021 @default.
• W2026703040 countsByYear W20267030402022 @default.
• W2026703040 countsByYear W20267030402023 @default.
• W2026703040 crossrefType "journal-article" @default.
• W2026703040 hasAuthorship W2026703040A5000062644 @default.
• W2026703040 hasAuthorship W2026703040A5035802220 @default.
• W2026703040 hasAuthorship W2026703040A5063767450 @default.
• W2026703040 hasConcept C104317684 @default.
• W2026703040 hasConcept C113246987 @default.
• W2026703040 hasConcept C134459356 @default.
• W2026703040 hasConcept C135903288 @default.
• W2026703040 hasConcept C169760540 @default.
• W2026703040 hasConcept C202751555 @default.
• W2026703040 hasConcept C25602115 @default.
• W2026703040 hasConcept C2776281502 @default.
• W2026703040 hasConcept C2777609662 @default.
• W2026703040 hasConcept C2779530196 @default.
• W2026703040 hasConcept C2779549131 @default.
• W2026703040 hasConcept C54355233 @default.
• W2026703040 hasConcept C62478195 @default.
• W2026703040 hasConcept C69125201 @default.
• W2026703040 hasConcept C86554907 @default.
• W2026703040 hasConcept C86803240 @default.
• W2026703040 hasConcept C94487597 @default.
• W2026703040 hasConcept C95444343 @default.
• W2026703040 hasConceptScore W2026703040C104317684 @default.
• W2026703040 hasConceptScore W2026703040C113246987 @default.
• W2026703040 hasConceptScore W2026703040C134459356 @default.
• W2026703040 hasConceptScore W2026703040C135903288 @default.
• W2026703040 hasConceptScore W2026703040C169760540 @default.
• W2026703040 hasConceptScore W2026703040C202751555 @default.
• W2026703040 hasConceptScore W2026703040C25602115 @default.
• W2026703040 hasConceptScore W2026703040C2776281502 @default.
• W2026703040 hasConceptScore W2026703040C2777609662 @default.
• W2026703040 hasConceptScore W2026703040C2779530196 @default.
• W2026703040 hasConceptScore W2026703040C2779549131 @default.
• W2026703040 hasConceptScore W2026703040C54355233 @default.

• next