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- W2026703551 abstract "Newborns are believed to have a higher gastrointestinal uptake of inorganic cadmium (Cd) than adults. However, relevant models for investigations of absorption of dietary Cd in neonates are lacking. In the present study, piglets were exposed to 2 or 20 μg Cd/kg body weight (b wt) per day by repeated oral administrations of CdCl2 dissolved in deionized water or infant follow-up formula from days 0 to 10. Elevated and dose-dependent Cd retention in blood and tissues resulted from this low-dose Cd exposure, as determined at day 11. Follow-up formula reduced Cd uptake in comparison to deionized water. However, Cd distribution to the kidneys was higher when Cd was given in formula than in water. Metallothionein (MT) levels in liver, kidney and duodenum were six, three and two times higher, respectively compared to an un-exposed control. Differences in bioavailability and distribution of low-dose Cd given in various diets to newborns could be detected by the proposed piglet model." @default.
- W2026703551 created "2016-06-24" @default.
- W2026703551 creator A5027764784 @default.
- W2026703551 creator A5029284108 @default.
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- W2026703551 date "2004-02-01" @default.
- W2026703551 modified "2023-10-17" @default.
- W2026703551 title "A piglet model for studies of gastrointestinal uptake of cadmium in neonates" @default.
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- W2026703551 doi "https://doi.org/10.1016/j.toxlet.2003.10.007" @default.
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