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- W2026708997 abstract "In cells of the immune system, calcium signals are essential for diverse cellular functions including differentiation, effector function, and gene transcription. After the engagement of immunoreceptors such as T-cell and B-cell antigen receptors and the Fc receptors on mast cells and NK cells, the intracellular concentration of calcium ions is increased through the sequential operation of two interdependent processes: depletion of endoplasmic reticulum Ca(2+) stores as a result of binding of inositol trisphosphate (IP(3)) to IP(3) receptors, followed by 'store-operated' Ca(2+) entry through plasma membrane Ca(2+) channels. In lymphocytes, mast cells and other immune cell types, store-operated Ca(2+) entry through specialized Ca(2+) release-activated calcium (CRAC) channels constitutes the major pathway of intracellular Ca(2+) increase. A recent breakthrough in our understanding of CRAC channel function is the identification of stromal interaction molecule (STIM) and ORAI, two essential regulators of CRAC channel function. This review focuses on the signaling pathways upstream and downstream of Ca(2+) influx (the STIM/ORAI and calcineurin/NFAT pathways, respectively)." @default.
- W2026708997 created "2016-06-24" @default.
- W2026708997 creator A5043886648 @default.
- W2026708997 creator A5080472610 @default.
- W2026708997 date "2008-06-01" @default.
- W2026708997 modified "2023-10-05" @default.
- W2026708997 title "Calcium signaling in lymphocytes" @default.
- W2026708997 cites W1500581977 @default.
- W2026708997 cites W1504215273 @default.
- W2026708997 cites W1539668795 @default.
- W2026708997 cites W1573590097 @default.
- W2026708997 cites W174512153 @default.
- W2026708997 cites W1773386990 @default.
- W2026708997 cites W1964287631 @default.
- W2026708997 cites W1978593035 @default.
- W2026708997 cites W1979573280 @default.
- W2026708997 cites W1980445622 @default.
- W2026708997 cites W1984670510 @default.
- W2026708997 cites W1985677612 @default.
- W2026708997 cites W1986060421 @default.
- W2026708997 cites W1987684167 @default.
- W2026708997 cites W1988523658 @default.
- W2026708997 cites W1993298907 @default.
- W2026708997 cites W2011593699 @default.
- W2026708997 cites W2012471725 @default.
- W2026708997 cites W2012790485 @default.
- W2026708997 cites W2017823454 @default.
- W2026708997 cites W2018628082 @default.
- W2026708997 cites W2019077533 @default.
- W2026708997 cites W2020708758 @default.
- W2026708997 cites W2028649950 @default.
- W2026708997 cites W2029149519 @default.
- W2026708997 cites W2029301182 @default.
- W2026708997 cites W2031966403 @default.
- W2026708997 cites W2033330205 @default.
- W2026708997 cites W2041474455 @default.
- W2026708997 cites W2041748354 @default.
- W2026708997 cites W2042144124 @default.
- W2026708997 cites W2042342392 @default.
- W2026708997 cites W2052776731 @default.
- W2026708997 cites W2054723193 @default.
- W2026708997 cites W2056597149 @default.
- W2026708997 cites W2058622754 @default.
- W2026708997 cites W2059989081 @default.
- W2026708997 cites W2061851471 @default.
- W2026708997 cites W2069265397 @default.
- W2026708997 cites W2069800089 @default.
- W2026708997 cites W2071709931 @default.
- W2026708997 cites W2072869294 @default.
- W2026708997 cites W2073580835 @default.
- W2026708997 cites W2076171916 @default.
- W2026708997 cites W2077111687 @default.
- W2026708997 cites W2079071687 @default.
- W2026708997 cites W2079491737 @default.
- W2026708997 cites W2083148444 @default.
- W2026708997 cites W2083391898 @default.
- W2026708997 cites W2090018138 @default.
- W2026708997 cites W2092987197 @default.
- W2026708997 cites W2093902610 @default.
- W2026708997 cites W2094980526 @default.
- W2026708997 cites W2095745067 @default.
- W2026708997 cites W2097265484 @default.
- W2026708997 cites W2101586949 @default.
- W2026708997 cites W2102847281 @default.
- W2026708997 cites W2104134181 @default.
- W2026708997 cites W2105299204 @default.
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- W2026708997 cites W2109495864 @default.
- W2026708997 cites W2110248507 @default.
- W2026708997 cites W2116015828 @default.
- W2026708997 cites W2118988881 @default.
- W2026708997 cites W2120959166 @default.
- W2026708997 cites W2140895729 @default.
- W2026708997 cites W2146341872 @default.
- W2026708997 cites W2152244674 @default.
- W2026708997 cites W2154908692 @default.
- W2026708997 cites W2157479637 @default.
- W2026708997 cites W2157973267 @default.
- W2026708997 cites W2158652398 @default.
- W2026708997 cites W2159738116 @default.
- W2026708997 cites W2161210718 @default.
- W2026708997 cites W2163789582 @default.
- W2026708997 doi "https://doi.org/10.1016/j.coi.2008.04.004" @default.
- W2026708997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574011" @default.
- W2026708997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18515054" @default.
- W2026708997 hasPublicationYear "2008" @default.
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