FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026716308> ?p ?o ?g. }

• W2026716308 endingPage "744.e7" @default.
• W2026716308 startingPage "744.e1" @default.
• W2026716308 abstract "To clarify the potential of TRK-380 as a drug for overactive bladder in humans by evaluating the agonistic activities for human β-adrenergic receptors (β-ARs) and the relaxing effects on isolated detrusor strips.The agonistic activities for human β-ARs were evaluated in SK-N-MC cells (for human β(3)-ARs) and Chinese hamster ovary cells expressing human β(1)- or human β(2)-ARs using the cyclic adenosine monophosphate accumulation assay. The relaxing effects on the resting tension in isolated detrusor strips from humans, monkeys, dogs, and rats and on carbachol- or KCl-induced contractions in human detrusor strips were evaluated.In the cyclic adenosine monophosphate accumulation assay, the agonistic activity of TRK-380 for human β(3)-ARs was potent and equivalent to that of the potent nonselective β-AR agonist isoproterenol and superior to that of selective β(3)-AR agonists, such as BRL-37344 and CL316,243. TRK-380 showed no agonistic activity for human β(1)-ARs and a weak agonistic effect on human β(2)-ARs. In isolated detrusor strips, the concentration-dependent relaxing effects of TRK-380 on the resting tension were equivalent to those of isoproterenol in humans, monkeys, and dogs but weaker than the effects in rats. The selective β(3)-AR antagonist SR59230A shifted the concentration-response curve in a concentration-dependent manner to TRK-380 for the resting tension of human detrusor strips to the right. TRK-380 had a concentration-dependent relaxing effect on the contractile responses to carbachol and KCl in human detrusor strips.TRK-380 was a potent and selective human β(3)-AR agonist, and the isolated human detrusor relaxation was mainly mediated by activation of the β(3)-AR. Consequently, TRK-380 might be a promising compound for the treatment of overactive bladder." @default.
• W2026716308 created "2016-06-24" @default.
• W2026716308 creator A5004687590 @default.
• W2026716308 creator A5012247500 @default.
• W2026716308 creator A5013248485 @default.
• W2026716308 creator A5018624776 @default.
• W2026716308 creator A5028432382 @default.
• W2026716308 creator A5036725983 @default.
• W2026716308 creator A5043853187 @default.
• W2026716308 creator A5052673213 @default.
• W2026716308 creator A5055151557 @default.
• W2026716308 creator A5063182256 @default.
• W2026716308 creator A5063536929 @default.
• W2026716308 creator A5081502216 @default.
• W2026716308 creator A5086245420 @default.
• W2026716308 date "2012-03-01" @default.
• W2026716308 modified "2023-10-16" @default.
• W2026716308 title "Pharmacological Effect of TRK-380, a Novel Selective Human β3-Adrenoceptor Agonist, on Mammalian Detrusor Strips" @default.
• W2026716308 cites W1585587286 @default.
• W2026716308 cites W1967312126 @default.
• W2026716308 cites W1976806219 @default.
• W2026716308 cites W1980809057 @default.
• W2026716308 cites W1984693557 @default.
• W2026716308 cites W1988521032 @default.
• W2026716308 cites W1992879600 @default.
• W2026716308 cites W2002896923 @default.
• W2026716308 cites W2007886796 @default.
• W2026716308 cites W2013351819 @default.
• W2026716308 cites W2014996904 @default.
• W2026716308 cites W2028671417 @default.
• W2026716308 cites W2034271699 @default.
• W2026716308 cites W2042772357 @default.
• W2026716308 cites W2043328831 @default.
• W2026716308 cites W2070432389 @default.
• W2026716308 cites W2074323366 @default.
• W2026716308 cites W2087764890 @default.
• W2026716308 cites W2114957828 @default.
• W2026716308 cites W2119809361 @default.
• W2026716308 cites W2134928141 @default.
• W2026716308 cites W2140064768 @default.
• W2026716308 cites W2143238509 @default.
• W2026716308 cites W2154939993 @default.
• W2026716308 cites W2155381616 @default.
• W2026716308 cites W2169016904 @default.
• W2026716308 doi "https://doi.org/10.1016/j.urology.2011.08.080" @default.
• W2026716308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22197203" @default.
• W2026716308 hasPublicationYear "2012" @default.
• W2026716308 type Work @default.
• W2026716308 sameAs 2026716308 @default.
• W2026716308 citedByCount "29" @default.
• W2026716308 countsByYear W20267163082013 @default.
• W2026716308 countsByYear W20267163082014 @default.
• W2026716308 countsByYear W20267163082015 @default.
• W2026716308 countsByYear W20267163082016 @default.
• W2026716308 countsByYear W20267163082019 @default.
• W2026716308 countsByYear W20267163082020 @default.
• W2026716308 countsByYear W20267163082021 @default.
• W2026716308 countsByYear W20267163082022 @default.
• W2026716308 countsByYear W20267163082023 @default.
• W2026716308 crossrefType "journal-article" @default.
• W2026716308 hasAuthorship W2026716308A5004687590 @default.
• W2026716308 hasAuthorship W2026716308A5012247500 @default.
• W2026716308 hasAuthorship W2026716308A5013248485 @default.
• W2026716308 hasAuthorship W2026716308A5018624776 @default.
• W2026716308 hasAuthorship W2026716308A5028432382 @default.
• W2026716308 hasAuthorship W2026716308A5036725983 @default.
• W2026716308 hasAuthorship W2026716308A5043853187 @default.
• W2026716308 hasAuthorship W2026716308A5052673213 @default.
• W2026716308 hasAuthorship W2026716308A5055151557 @default.
• W2026716308 hasAuthorship W2026716308A5063182256 @default.
• W2026716308 hasAuthorship W2026716308A5063536929 @default.
• W2026716308 hasAuthorship W2026716308A5081502216 @default.
• W2026716308 hasAuthorship W2026716308A5086245420 @default.
• W2026716308 hasConcept C126322002 @default.
• W2026716308 hasConcept C134018914 @default.
• W2026716308 hasConcept C134139212 @default.
• W2026716308 hasConcept C170493617 @default.
• W2026716308 hasConcept C175656101 @default.
• W2026716308 hasConcept C2778938600 @default.
• W2026716308 hasConcept C2778988552 @default.
• W2026716308 hasConcept C2779762690 @default.
• W2026716308 hasConcept C2780616540 @default.
• W2026716308 hasConcept C71924100 @default.
• W2026716308 hasConcept C92020748 @default.
• W2026716308 hasConceptScore W2026716308C126322002 @default.
• W2026716308 hasConceptScore W2026716308C134018914 @default.
• W2026716308 hasConceptScore W2026716308C134139212 @default.
• W2026716308 hasConceptScore W2026716308C170493617 @default.
• W2026716308 hasConceptScore W2026716308C175656101 @default.
• W2026716308 hasConceptScore W2026716308C2778938600 @default.
• W2026716308 hasConceptScore W2026716308C2778988552 @default.
• W2026716308 hasConceptScore W2026716308C2779762690 @default.
• W2026716308 hasConceptScore W2026716308C2780616540 @default.
• W2026716308 hasConceptScore W2026716308C71924100 @default.
• W2026716308 hasConceptScore W2026716308C92020748 @default.
• W2026716308 hasIssue "3" @default.
• W2026716308 hasLocation W20267163081 @default.
• W2026716308 hasLocation W20267163082 @default.

• next