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- W2026723853 abstract "Abstract In this report, we analysed the suitability of collagen immunohistochemistry for the determination of collagen stability in historic bone specimens. The analysis covered the immunolocalization of the collagen types I, III, IV and in some specimens also of collagen VI in bone tissue ranging between 16,000 bc (Olduvai) to 1200 ad (Peru). Specific positive reactions were seen first in bone samples from Hassek Hoyok (Southeast Turkey) dating from about 3000 bc . The intra- and interindividual range of positive reactions, however, was large, although specimens of “younger” age showed better conservation of the tissue structure and coincidentally more often a specific collagen type immunoreaction. Our analysis demonstrates that collagen immunohistochemistry may provide a specific method for the analysis of intactness of collagen molecules or defined fragments derived thereof. This technique thus provides considerable information on the molecular structure of historic bone tissue." @default.
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- W2026723853 date "1997-03-01" @default.
- W2026723853 modified "2023-10-04" @default.
- W2026723853 title "Suitability of Immunohistochemistry for the Determination of Collagen Stability in Historic Bone Tissue" @default.
- W2026723853 doi "https://doi.org/10.1006/jasc.1996.0110" @default.
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