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• W2026740797 abstract "La lipoproteína(a) (Lp [a]) es un factor de riesgo de enfermedad cardiovascular. El objetivo de nuestro estudio ha sido determinar la distribución de la Lp(a) en niños y su relación con variables antropométricas, factores lipídicos y trombogénicos. Se determinaron las concentraciones séricas de Lp(a), colesterol total, triglicéridos, colesterol unido a lipoproteínas de alta densidad (cHDL) colesterol unido a lipoproteínas de baja densidad (cLDL), fibrinógeno, dímero-D e inhibidor del activador del plasminógeno (PAI-1); así como el peso y la talla, en 98 niños/as de 6-7 años, todos ellos supuestamente sanos. Las concentraciones de Lp(a) variaron de 0,17 a 120 mg/dl, con una mediana y rango intercuartílico de 5,56 mg/dl (2,37-13,46). El 9,1% de los niños presentó concentraciones de Lp(a) superiores a 30 mg/dl, y los más elevados se encontraron en el grupo de niños con antecedentes familiares de enfermedad cardiovascular, sin llegar a ser la diferencia estadísticamente significativa. Encontramos una correlación positiva y significativa entre los valores de Lp(a) y de cLDL, y negativa y significativa con el peso. No encontramos correlación entre los valores de Lp(a) y los factores trombogénicos. Teniendo en cuenta el efecto aditivo de los factores de riesgo cardiovascular y después de observar los datos obtenidos, pensamos que debería considerarse la determinación de Lp(a) en los niños que presenten valores elevados de cLDL o antecedentes familiares de enfermedad cardiovascular. Lipoprotein(a) is a risk factor for cardiovascular disease. The purpose of this study was to determine the distribution of Lp(a) levels in children and to evaluate its relationship with anthropometric measures, and lipid and thrombogenic factors. Serum levels of Lp(a), total cholesterol, triglycerides, high-density lipoprotein (cHDL)-cholesterol, low-density lipoprotein (cLDL)-cholesterol, fibrinogen, D-dimer and plasminogen activator inhibitor (PAI-1), as well as weight and height, were measured in 98 apparently healthy boys and girls aged 6-7 years old. Serum Lp(a) levels ranged from 0.17 to 120 mg/dl (median: 5.56 mg/dl; interquartile range: 2.37-13.46). Levels higher than 30 mg/dl were found in 9.1% of the children. Lp(a) concentrations were higher in the group of children with a family history of cardiovascular disease, although this difference was not statistically significant. A positive and significant correlation was found between Lp(a) levels cLDL and a negative and significant correlation was found with weight. No correlation was observed between Lp(a) levels and thrombogenic factors. In view of the additive effect of cardiovascular risk factors and the data obtained in this study, we believe that Lp(a) determination should be considered in children with high LDL-c levels or a family history of cardiovascular disease." @default.
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• W2026740797 date "2006-06-01" @default.
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• W2026740797 title "Lipoproteína(a), variables antropométricas, parámetros lipídicos y trombogénicos en la infancia" @default.
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