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• W2026747812 abstract "In a crossover trial, eight patients were studied during one treatment each of automated peritoneal dialysis (APD) and hybrid dialysis (HyD). During HyD, a fixed quantity of peritoneal dialysis fluid (PDF) was continuously removed at a flow rate of 141.3 ± 23.7 mL/min, dialyzed against the secondary dialysate (250 ± 53.5 mL/min) generated by the hemodialysis delivery system with single-needle dialysis capability, and the regenerated PDF (PDFHyD ) was reinfused into the peritoneal cavity. Despite using a smaller volume (6,195 ± 737 versus 13,321 ± 1,201 mL; P < 0.0001) of PDFHyD with a lower glucose concentration (729 ± 562 versus 1,659 ± 373 mg/dL; P < 0.0001) and osmolality (331 ± 79 versus 387 ± 184 mOsm/kg; P < 0.001) during HyD compared with APD (PDFAPD ), weight loss was similar with both treatments (1.4 ± 1.0 versus 1.6 ± 1.2 kg). Lactate levels were lower (3.2 ± 2.5 versus 11.4 ± 5.4 mEq/L), but pH (7.5 ± 1.3 versus 5.6 ± 0.9; P < 0.001) and bicarbonate concentration (22.6 ± 8.0 versus 11.9 ± 7.9 mEq/L; P < 0.0001) were greater in PDFHyD than PDFAPD. Although the mean dialysate calcium level was lower (6.0 ± 0.5 versus 6.9 ± 1.1 mg/dL; P < 0.001) in PDFHyD , it was more stable throughout the dialysis compared with PDFAPD. A steeper concentration gradient between the blood and dialysate resulted in greater clearance of urea (26.5 ± 9.1 versus 11.0 ± 4.7 mL/min; P = 0.04), creatinine (24.1 ± 11.4 versus 12.0 ± 7.9 mL/min; P = 0.03), phosphate (19.2 ± 4.3 versus 9.8 ± 7.2 mL/min; P = 0.01), and uric acid (15.6 ± 6.9 versus 9.1 ± 2.7 mL/min; P = 0.04) and a greater percentage of reduction in values for blood urea nitrogen (20.7% ± 7.7% versus 11.6% ± 5.5%; P = 0.02), serum creatinine (16.1% ± 5.3% versus 6.6% ± 3.0%; P < 0.001), phosphate (22.7% ± 8.9% versus 9.8% ± 4.5%; P = 0.004), and uric acid (15.8% ± 2.9% versus 6.3% ± 3.4%; P < 0.001) during HyD than APD. To conclude, HyD is a novel dialytic technique that uses biocompatible bicarbonate-based dialysate to achieve excellent clearance of uremic toxins and ultrafiltration with minimal glucose load." @default.
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• W2026747812 date "2000-07-01" @default.
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• W2026747812 title "Hybrid dialysis: Recirculation peritoneal dialysis revisited" @default.
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• W2026747812 doi "https://doi.org/10.1053/ajkd.2000.8268" @default.
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